Adenomyosis As a Confounder to Accurate Endometrial Cancer Staging

Mahmoud A Khalifa, Mostafa Atri, Molly E Klein, Sayak Ghatak, Paari Murugan

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The coexistence of endometrial adenocarcinoma and adenomyosis in the same uterus is a common phenomenon. In many of such affected patients foci of adenomyosis could also be colonized by adenocarcinoma. The various permutations arising from these scenarios pose preoperative imaging and postoperative pathologic staging challenges. This article aims to raise awareness of these staging issues and lists some of the relevant practical approaches. Adenomyosis reduces the accuracy of magnetic resonance imaging in assessing the depth of invasion as it reduces the contrast between the endometrial cancer adenomyosis-involved myometrium. The article also offers an alternate argument for staging cancers where myoinvasion is found deep in the myometrium, arising from cancer-positive adenomyotic foci when the surface tumor is either limited to the endometrium or to the inner half of myometrium.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalSeminars in Ultrasound, CT and MRI
Issue number4
StatePublished - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.


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