Adeno-Associated Viral Vectors in Neuroscience Research

David L. Haggerty; Gregory G. Grecco; Kaitlin C. Reeves; Brady Atwood

doi:10.1016/j.omtm.2019.11.012

Adeno-Associated Viral Vectors in Neuroscience Research

David L. Haggerty, Gregory G. Grecco, Kaitlin C. Reeves, Brady Atwood

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.

Original language	English (US)
Pages (from-to)	69-82
Number of pages	14
Journal	Molecular Therapy Methods and Clinical Development
Volume	17
DOIs	https://doi.org/10.1016/j.omtm.2019.11.012
State	Published - Jun 12 2020
Externally published	Yes

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abstract = "Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.",

author = "Haggerty, {David L.} and Grecco, {Gregory G.} and Reeves, {Kaitlin C.} and Brady Atwood",

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T1 - Adeno-Associated Viral Vectors in Neuroscience Research

AU - Haggerty, David L.

AU - Grecco, Gregory G.

AU - Reeves, Kaitlin C.

AU - Atwood, Brady

PY - 2020/6/12

Y1 - 2020/6/12

N2 - Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.

AB - Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.

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U2 - 10.1016/j.omtm.2019.11.012

DO - 10.1016/j.omtm.2019.11.012

M3 - Review article

AN - SCOPUS:85076507497

SN - 2329-0501

VL - 17

SP - 69

EP - 82

JO - Molecular Therapy Methods and Clinical Development

JF - Molecular Therapy Methods and Clinical Development

ER -

Adeno-Associated Viral Vectors in Neuroscience Research

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