Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency

Bolajoko O. Olusanya, Abieyuwa A. Emokpae, Tara G. Zamora, Tina M. Slusher

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. Conclusion Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.

Original languageEnglish (US)
Pages (from-to)1102-1109
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics
Volume103
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • Acute bilirubin encephalopathy
  • Child disability
  • Developing countries
  • Kernicterus
  • Phototherapy

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