Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency

Bolajoko O. Olusanya, Abieyuwa A. Emokpae, Tara G. Zamora, Tina M. Slusher

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. Conclusion Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.

Original languageEnglish (US)
Pages (from-to)1102-1109
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics
Volume103
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Neonatal Hyperbilirubinemia
Glucosephosphate Dehydrogenase Deficiency
Hyperbilirubinemia
Infant Mortality
Jaundice
Morbidity
Mortality

Keywords

  • Acute bilirubin encephalopathy
  • Child disability
  • Developing countries
  • Kernicterus
  • Phototherapy

Cite this

Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency. / Olusanya, Bolajoko O.; Emokpae, Abieyuwa A.; Zamora, Tara G.; Slusher, Tina M.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 103, No. 11, 01.11.2014, p. 1102-1109.

Research output: Contribution to journalReview article

@article{bd362f06f31d41d895b773357ea18276,
title = "Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency",
abstract = "Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10{\%} or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. Conclusion Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.",
keywords = "Acute bilirubin encephalopathy, Child disability, Developing countries, Kernicterus, Phototherapy",
author = "Olusanya, {Bolajoko O.} and Emokpae, {Abieyuwa A.} and Zamora, {Tara G.} and Slusher, {Tina M.}",
year = "2014",
month = "11",
day = "1",
doi = "10.1111/apa.12735",
language = "English (US)",
volume = "103",
pages = "1102--1109",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency

AU - Olusanya, Bolajoko O.

AU - Emokpae, Abieyuwa A.

AU - Zamora, Tara G.

AU - Slusher, Tina M.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. Conclusion Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.

AB - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. Conclusion Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.

KW - Acute bilirubin encephalopathy

KW - Child disability

KW - Developing countries

KW - Kernicterus

KW - Phototherapy

UR - http://www.scopus.com/inward/record.url?scp=84922878411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922878411&partnerID=8YFLogxK

U2 - 10.1111/apa.12735

DO - 10.1111/apa.12735

M3 - Review article

C2 - 24990658

AN - SCOPUS:84922878411

VL - 103

SP - 1102

EP - 1109

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 11

ER -