Addressing pediatric hiv pretreatment drug resistance and virologic failure in sub-saharan africa: A cost-effectiveness analysis of diagnostic-based strategies in children ≥3 years old

Mutita Siriruchatanon, Shan Liu, James G. Carlucci, Eva A. Enns, Horacio A. Duarte

Research output: Contribution to journalArticlepeer-review

Abstract

Improvement of antiretroviral therapy (ART) regimen switching practices and implementation of pretreatment drug resistance (PDR) testing are two potential approaches to improve health outcomes for children living with HIV. We developed a microsimulation model of disease progression and treatment focused on children with perinatally acquired HIV in sub-Saharan Africa who initiate ART at 3 years of age. We evaluated the cost-effectiveness of diagnostic-based strategies (improved switching and PDR testing), over a 10-year time horizon, in settings without and with pediatric dolutegravir (DTG) availability as first-line ART. The improved switching strategy increases the probability of switching to second-line ART when virologic failure is diagnosed through viral load testing. The PDR testing strategy involves a one-time PDR test prior to ART initiation to guide choice of initial regimen. When DTG is not available, PDR testing is dominated by the improved switching strategy, which has an incremental cost-effectiveness ratio (ICER) of USD 579/life-year gained (LY), relative to the status quo. If DTG is available, improved switching has a similar ICER (USD 591/LY) relative to the DTG status quo. Even when substantial financial investment is needed to achieve improved regimen switching practices, the improved switching strategy still has the potential to be cost-effective in a wide range of sub-Saharan African countries. Our analysis highlights the importance of strengthening existing laboratory monitoring systems to improve the health of children living with HIV.

Original languageEnglish (US)
Article number567
JournalDiagnostics
Volume11
Issue number3
DOIs
StatePublished - Mar 2021

Bibliographical note

Funding Information:
Funding: This research was funded in part by a 2018 developmental grant from the University of Washington/Fred Hutch Center for AIDS Research, a National Institutes of Health-funded program under award number AI027757, which is supported by the following NIH Institutes and Centers: National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institute of Mental Health, National Institute on Drug Abuse, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Institute on Aging, National Institute of General Medical Sciences, and National Institute of Diabetes and Digestive and Kidney Diseases. A Gilead HIV Research Scholars Program Award and a PhRMA Foundation Health Outcomes Research Starter Grant also supported this work. Finally, partial support for this research came from a Eunice Kennedy Shriver National Institute of Child Health and Human Development research infrastructure grant, P2C HD042828, to the Center for Studies in Demography and Ecology at the University of Washington.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Africa
  • Dolutegravir-based ART
  • Drug resistance testing
  • HIV
  • NNRTIbased ART
  • Pretreatment drug resistance
  • Regimen switching
  • Virologic failure

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