Additive-Free Palladium-Catalyzed Decarboxylative Cross-Coupling of Aryl Chlorides

Ryan A. Daley, En Chih Liu, Joseph J. Topczewski

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The cross-coupling of sodium (hetero)aryl carboxylates with (hetero)aryl chlorides proceeds with 1 mol % palladium catalyst and does not require inorganic base, silver salts, or copper salts. This coupling uses two low energy partners, and the only stoichiometric byproducts are carbon dioxide and sodium chloride. The substrate scope includes less activated aryl chlorides and carboxylates (>25 examples). The palladium loading could be reduced to 0.1 mol %, and Buchwald-style precatalysts could be used.

Original languageEnglish (US)
Pages (from-to)4734-4738
Number of pages5
JournalOrganic Letters
Issue number12
StatePublished - Jun 21 2019

Bibliographical note

Funding Information:
Financial support was provided by the University of Minnesota.

Publisher Copyright:
© 2019 American Chemical Society.


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