Addiction, Pain, and Stress Response

Research output: Chapter in Book/Report/Conference proceedingChapter


Experience of stress and pain is mediated through multiple levels, including genetic, biological, cognitive, behavioral, and social factors. Substance abuse poses threats to health, social, and economic welfare. Research studies show that administration of abused drugs induces various neurochemical changes in the brain that produce alteration in the stress response and pain sensitivity. While acute administration of drugs of abuse inhibits pain, repetitive or chronic intake develops tolerance to the drug that could influence drug-related analgesia and drug relapse. This chapter is aimed at providing a general overview of how drug use and misuse are associated with pain and stress and discusses findings from studies showing the mediating role of stress in the link between pain and addiction. Finally, other factors such as sex differences and mental health problems that modify the associations between drug use, pain, and stress are discussed.

Original languageEnglish (US)
Title of host publicationThe Neuroscience of Pain, Stress, and Emotion
Subtitle of host publicationPsychological and Clinical Implications
PublisherElsevier Inc.
Number of pages27
ISBN (Print)9780128005385
StatePublished - Jan 4 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.


  • Addiction
  • Pain
  • Stress
  • Stress-induced analgesia
  • Substance use


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