Adaptor proteins in lymphocyte antigen-receptor signaling

Erik J. Peterson, James L. Clements, Nan Fang, Gary A. Koretzky

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Adaptor molecules, proteins that possess no intrinsic enzymatic function, but which mediate protein-protein interactions, have a critical role in integrating signal transduction pathways following engagement of cell-surface receptors. Several newly described adaptor molecules have been shown to serve important functions in the regulation of signaling events initiated by lymphocyte antigen receptors. Understanding how these adaptor proteins function to modulate signaling cascades will provide important insights into the complex biology or lymphocyte activation.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1998

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