Adaptive third-order Volterra filter for detection and tracking of nonlinear oscillations in ultrasound echo data

Juan Du, John R. Ballard, Jeunghwan Choi, John C. Bischof, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Microbubble ultrasound contrast agents (UCAs) have been extensively used in medical ultrasound for enhancing the echo components from blood vessels. However, their ultimate promise of enhancing the echoes from the microvasculature with high specificity remains unfulfilled using existing methods. We have previously shown that the Volterra filter can be used to enhance UCA echo components from flow channels with dimensions similar to peripheral vessels, e.g. the carotid artery. In this paper, we investigate a new receiver architecture based on an adaptive third-order Volterra Filter (VF) in conjunction with beamformed echo data from imaging tumor microvasculature in vivo. It is shown that the cubic and quadratic components of the VF provide significant enhancement of the UCA echoes from the tumor compared to the echoes from the same tissue regions in the absence of the UCA. We describe an adaptive recursive least squares (RLS) implementation of the VF and give examples of the contrast enhancement. Further enhancement of the UCA contrast is achieved by applying a dynamic statistical decision rule that produces a parameter we refer to as the temporal perfusion index (TPI). The TPI rewards transient echo oscillations while rejecting tissue motion and noise variation. These in vivo results demonstrate the potential for advanced signal processing in increasing the sensitivity and specificity of medical ultrasound in imaging tissue perfusion, a form of functional imaging.

Original languageEnglish (US)
Title of host publication2013 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2013 - Proceedings
Pages1051-1055
Number of pages5
DOIs
StatePublished - Oct 18 2013
Event2013 38th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2013 - Vancouver, BC, Canada
Duration: May 26 2013May 31 2013

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
ISSN (Print)1520-6149

Other

Other2013 38th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2013
CountryCanada
CityVancouver, BC
Period5/26/135/31/13

Keywords

  • Functional Imaging
  • Nonlinear Signal Processing
  • Postbeamforming Filter Banks
  • Ultrasound Imaging

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