Adaptive immunity to cryptococcus neoformans infections

Liliane Mukaremera, Kirsten Nielsen

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal pathogens with different phenotypic and genotypic diversity that cause disease in immunocompromised patients as well as in healthy individuals. The immune response resulting from the interaction between Cryptococcus and the host immune system is a key determinant of the disease outcome. The species C. neoformans causes the majority of human infections, and therefore almost all immunological studies focused on C. neoformans infections. Thus, this review presents current understanding on the role of adaptive immunity during C. neoformans infections both in humans and in animal models of disease.

Original languageEnglish (US)
Article number64
JournalJournal of Fungi
Issue number4
StatePublished - Dec 2017

Bibliographical note

Funding Information:
The writing of this review was supported by National Institute of Health grants AI080275 and AI122352 to Kirsten Nielsen.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Adaptive immunity
  • CD4
  • Cryptococcus
  • Cytokines
  • Dendritic cells
  • Helper T cell type 1 (Th1)
  • Helper T cell type 17 (Th17)
  • Helper T cell type 2 (Th2)
  • Immune reconstitution inflammatory syndrome (IRIS)


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