Adaptation of pandemic H2N2 influenza A viruses in humans

CEIRS H2N2 Working Group

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.

Original languageEnglish (US)
Pages (from-to)2442-2447
Number of pages6
JournalJournal of virology
Issue number4
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015, American Society for Microbiology.


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