Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

William J. Hoekstra, Jeffery B. Press, Mary Pat Bonner, Patricia Andrade-Gordon, Patricia M. Keane, Kathleen A. Durkin, Dennis C. Liotta, Kevin H. Mayo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406-409 KQAG region of the γ-chain of fibrinogen which appears as a β-turn in solution NMR structures of Fg-γ385-411.

Original languageEnglish (US)
Pages (from-to)1361-1364
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
StatePublished - Jun 9 1994


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