Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

William J. Hoekstra; Jeffery B. Press; Mary Pat Bonner; Patricia Andrade-Gordon; Patricia M. Keane; Kathleen A. Durkin; Dennis C. Liotta; Kevin H. Mayo

doi:10.1016/S0960-894X(01)80362-0

Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

William J. Hoekstra, Jeffery B. Press, Mary Pat Bonner, Patricia Andrade-Gordon, Patricia M. Keane, Kathleen A. Durkin, Dennis C. Liotta, Kevin H. Mayo

Biochemistry, Molecular Biology, and Biophysics (TMED)

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Abstract

1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406-409 KQAG region of the γ-chain of fibrinogen which appears as a β-turn in solution NMR structures of Fg-γ385-411.

Original language	English (US)
Pages (from-to)	1361-1364
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(01)80362-0
State	Published - Jun 9 1994

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title = "Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics",

abstract = "1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406-409 KQAG region of the γ-chain of fibrinogen which appears as a β-turn in solution NMR structures of Fg-γ385-411.",

author = "Hoekstra, {William J.} and Press, {Jeffery B.} and Bonner, {Mary Pat} and Patricia Andrade-Gordon and Keane, {Patricia M.} and Durkin, {Kathleen A.} and Liotta, {Dennis C.} and Mayo, {Kevin H.}",

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AU - Hoekstra, William J.

AU - Press, Jeffery B.

AU - Bonner, Mary Pat

AU - Andrade-Gordon, Patricia

AU - Keane, Patricia M.

AU - Durkin, Kathleen A.

AU - Liotta, Dennis C.

AU - Mayo, Kevin H.

PY - 1994/6/9

Y1 - 1994/6/9

N2 - 1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406-409 KQAG region of the γ-chain of fibrinogen which appears as a β-turn in solution NMR structures of Fg-γ385-411.

AB - 1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406-409 KQAG region of the γ-chain of fibrinogen which appears as a β-turn in solution NMR structures of Fg-γ385-411.

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U2 - 10.1016/S0960-894X(01)80362-0

DO - 10.1016/S0960-894X(01)80362-0

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EP - 1364

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

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