Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

R. Karl Dieter, Ram R. Sharma, Wendy Ryan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

Original languageEnglish (US)
Pages (from-to)783-786
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number5
DOIs
StatePublished - Feb 3 1997
Externally publishedYes

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