Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

R. Karl Dieter; Ram R. Sharma; Wendy Ryan

doi:10.1016/S0040-4039(96)02411-2

Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

R. Karl Dieter, Ram R. Sharma, Wendy Ryan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

Original language	English (US)
Pages (from-to)	783-786
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/S0040-4039(96)02411-2
State	Published - Feb 3 1997
Externally published	Yes

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title = "Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts",

abstract = "α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.",

author = "Dieter, {R. Karl} and Sharma, {Ram R.} and Wendy Ryan",

year = "1997",

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doi = "10.1016/S0040-4039(96)02411-2",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides

T2 - Improved yields with soluble copper (I) salts

AU - Dieter, R. Karl

AU - Sharma, Ram R.

AU - Ryan, Wendy

PY - 1997/2/3

Y1 - 1997/2/3

N2 - α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

AB - α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

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U2 - 10.1016/S0040-4039(96)02411-2

DO - 10.1016/S0040-4039(96)02411-2

M3 - Article

AN - SCOPUS:0031026357

SN - 0040-4039

VL - 38

SP - 783

EP - 786

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

ER -

Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

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