Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

Sarah J. Ryan; Sydonie D. Schimler; Douglas C. Bland; Melanie S. Sanford

doi:10.1021/acs.orglett.5b00538

Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

Sarah J. Ryan, Sydonie D. Schimler, Douglas C. Bland, Melanie S. Sanford

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature S_NAr fluorination of a variety of aryl chlorides and nitroarenes.

Original language	English (US)
Pages (from-to)	1866-1869
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	8
DOIs	https://doi.org/10.1021/acs.orglett.5b00538
State	Published - Apr 17 2015

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© 2015 American Chemical Society.

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abstract = "The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.",

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AU - Sanford, Melanie S.

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AB - The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.

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Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

Abstract

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