Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

Sarah J. Ryan, Sydonie D. Schimler, Douglas C. Bland, Melanie S. Sanford

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.

Original languageEnglish (US)
Pages (from-to)1866-1869
Number of pages4
JournalOrganic Letters
Volume17
Issue number8
DOIs
StatePublished - Apr 17 2015

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