Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

Russell J. Erickson; David R. Mount; Terry L. Highland; J. Russell Hockett; Dale J. Hoff; Correne T. Jenson; Teresa J. Norberg-King; Brandy Forsman

doi:10.1002/etc.5389

Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

Russell J. Erickson
, David R. Mount
, Terry L. Highland
, J. Russell Hockett
, Dale J. Hoff
, Correne T. Jenson
, Teresa J. Norberg-King
, Brandy Forsman

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mathematical models are presented for the acute median lethal concentrations of major geochemical ions (Na⁺, K⁺, Ca²⁺, Mg²⁺, Cl⁻, SO₄²⁻, HCO₃⁻/CO₃²⁻) to fathead minnows (Pimephales promelas), based on an extensive series of experiments presented in a companion article. Toxicity relationships across different dilution waters, individual salts, and salt mixtures suggest six independent mechanisms of toxicity to consider in modeling efforts, including Mg/Ca-specific toxicity, osmolarity-related toxicity, SO₄-specific toxicity, K-specific toxicity, effects of high pH/alkalinity, and a multiple ion-related toxicity at low Ca distinct from the other mechanisms. Models are evaluated using chemical activity-based exposure metrics pertinent to each mechanism, but concentration-based alternative models that are simpler to apply are also addressed. These models are compared to those previously provided for Ceriodaphnia dubia, and various issues regarding their application to risk assessments are discussed. Environ Toxicol Chem 2022;41:2095–2106.

Original language	English (US)
Pages (from-to)	2095-2106
Number of pages	12
Journal	Environmental Toxicology and Chemistry
Volume	41
Issue number	9
DOIs	https://doi.org/10.1002/etc.5389
State	Published - Sep 2022
Externally published	Yes

Bibliographical note

Funding Information:
The authors wish to thank K. Lott for supervising the culture of test organisms used in the present study and to J. Nichols, J. Lazorchak, and 3 anonymous referees for helpful reviews.

Publisher Copyright:
© 2022 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Keywords

Aquatic toxicology
Fathead minnow
Major geochemical ions
Mathematical models
Mixture toxicity
Pimephales promelas
Toxicity mechanisms
Humans
Cladocera
Ions
Toxicity Tests, Acute
Animals
Cyprinidae
Water Pollutants, Chemical/chemistry

PubMed: MeSH publication types

Journal Article

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10.1002/etc.5389

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title = "Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity",

abstract = "Mathematical models are presented for the acute median lethal concentrations of major geochemical ions (Na+, K+, Ca2+, Mg2+, Cl−, SO42−, HCO3−/CO32−) to fathead minnows (Pimephales promelas), based on an extensive series of experiments presented in a companion article. Toxicity relationships across different dilution waters, individual salts, and salt mixtures suggest six independent mechanisms of toxicity to consider in modeling efforts, including Mg/Ca-specific toxicity, osmolarity-related toxicity, SO4-specific toxicity, K-specific toxicity, effects of high pH/alkalinity, and a multiple ion-related toxicity at low Ca distinct from the other mechanisms. Models are evaluated using chemical activity-based exposure metrics pertinent to each mechanism, but concentration-based alternative models that are simpler to apply are also addressed. These models are compared to those previously provided for Ceriodaphnia dubia, and various issues regarding their application to risk assessments are discussed. Environ Toxicol Chem 2022;41:2095–2106. ",

keywords = "Aquatic toxicology, Fathead minnow, Major geochemical ions, Mathematical models, Mixture toxicity, Pimephales promelas, Toxicity mechanisms, Humans, Cladocera, Ions, Toxicity Tests, Acute, Animals, Cyprinidae, Water Pollutants, Chemical/chemistry",

author = "Erickson, \{Russell J.\} and Mount, \{David R.\} and Highland, \{Terry L.\} and Hockett, \{J. Russell\} and Hoff, \{Dale J.\} and Jenson, \{Correne T.\} and Norberg-King, \{Teresa J.\} and Brandy Forsman",

note = "Funding Information: The authors wish to thank K. Lott for supervising the culture of test organisms used in the present study and to J. Nichols, J. Lazorchak, and 3 anonymous referees for helpful reviews. Publisher Copyright: {\textcopyright} 2022 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.",

year = "2022",

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T2 - Part B—Modeling Ion Toxicity

AU - Erickson, Russell J.

AU - Mount, David R.

AU - Highland, Terry L.

AU - Hockett, J. Russell

AU - Hoff, Dale J.

AU - Jenson, Correne T.

AU - Norberg-King, Teresa J.

AU - Forsman, Brandy

N1 - Funding Information: The authors wish to thank K. Lott for supervising the culture of test organisms used in the present study and to J. Nichols, J. Lazorchak, and 3 anonymous referees for helpful reviews. Publisher Copyright: © 2022 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

PY - 2022/9

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N2 - Mathematical models are presented for the acute median lethal concentrations of major geochemical ions (Na+, K+, Ca2+, Mg2+, Cl−, SO42−, HCO3−/CO32−) to fathead minnows (Pimephales promelas), based on an extensive series of experiments presented in a companion article. Toxicity relationships across different dilution waters, individual salts, and salt mixtures suggest six independent mechanisms of toxicity to consider in modeling efforts, including Mg/Ca-specific toxicity, osmolarity-related toxicity, SO4-specific toxicity, K-specific toxicity, effects of high pH/alkalinity, and a multiple ion-related toxicity at low Ca distinct from the other mechanisms. Models are evaluated using chemical activity-based exposure metrics pertinent to each mechanism, but concentration-based alternative models that are simpler to apply are also addressed. These models are compared to those previously provided for Ceriodaphnia dubia, and various issues regarding their application to risk assessments are discussed. Environ Toxicol Chem 2022;41:2095–2106.

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KW - Aquatic toxicology

KW - Fathead minnow

KW - Major geochemical ions

KW - Mathematical models

KW - Mixture toxicity

KW - Pimephales promelas

KW - Toxicity mechanisms

KW - Humans

KW - Cladocera

KW - Ions

KW - Toxicity Tests, Acute

KW - Animals

KW - Cyprinidae

KW - Water Pollutants, Chemical/chemistry

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AN - SCOPUS:85135213383

SN - 0730-7268

VL - 41

SP - 2095

EP - 2106

JO - Environmental Toxicology and Chemistry

JF - Environmental Toxicology and Chemistry

IS - 9

ER -

Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

Abstract

Bibliographical note

Keywords

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