Acute stroke reperfusion therapy trends in the expanded treatment window era

Ganesh Asaithambi, Xin Tong, Mary G. George, Albert W. Tsai, James M. Peacock, Russell V. Luepker, Kamakshi Lakshminarayan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: The American Heart Association/American Stroke Association (AHA/ ASA) recommended an expansion of the time window for acute ischemic stroke (AIS) reperfusion with intravenous (IV) recombinant tissue plasminogen activator (rt-PA) from 3 to 4.5 hours after symptom onset. We examine rates of IV and intraarterial (IA) reperfusion before and after the recommendations to track guideline adoption in community practice.

Methods: Patients with AIS in the Paul Coverdell National Acute Stroke Registry spanning years 2007-2012 were identified. Trends in rates of IVrt-PAversus IA therapy were examined. Outcomes included symptomatic intracerebral hemorrhage (sICH), in-hospital mortality, ability to ambulate at discharge, and discharge destination.

Results: From 2007 to 2012, there were 182,235 AIS patients (median age, 72 years; 51.5% women) in the database at the time of analysis. AIS patients receiving IV rt-PA increased significantly from 3.7% in 2007 to 5.1% in 2012 in the ≤3 hours time window and from .2% in 2007 to 1.3% in 2012 in the 3-4.5 hours time window (P<.001 for both). There was also a significant increase in the rate of IA therapy between 2007 and 2012 (P<.001). There was a significant decrease in the rate of sICH among patients who received any reperfusion between 2007 and 2012.

Conclusions: There was a trend for increased utilization of IV rt-PA in the 0-3 hours and the 3-4.5 hours time windows, which began around the same time as the publication of AHA/ASA recommendations in 2009. This increase was associated with an increase in IA treatment rates along with a decrease in overall sICH rates for patients receiving any reperfusion.

Original languageEnglish (US)
Pages (from-to)2316-2321
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume23
Issue number9
DOIs
StatePublished - Oct 1 2014

Bibliographical note

Publisher Copyright:
© 2014 National Stroke Association.

Keywords

  • Expanded time window
  • ischemic stroke
  • thrombolysis
  • trend analysis

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