TY - JOUR
T1 - Acute splenic complications and implications of splenectomy in hemoglobin SC disease
AU - Subbannan, Karthi
AU - Ustun, Celalettin
AU - Natarajan, Kavita
AU - Clair, Betsy
AU - Daitch, Lisa
AU - Fields, Sabine
AU - Kutlar, Ferdane
AU - Kutlar, Abdullah
PY - 2009/9
Y1 - 2009/9
N2 - Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 gdL vs. 12.5 gdL, P < 0.0001), platelet counts (median 146 × 106L vs. 275 × 106L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.
AB - Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 gdL vs. 12.5 gdL, P < 0.0001), platelet counts (median 146 × 106L vs. 275 × 106L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.
KW - Hemoglobin SC disease
KW - Splenectomy
KW - Splenic hemorrhage
KW - Splenic infarct
UR - http://www.scopus.com/inward/record.url?scp=68849126870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68849126870&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.2009.01270.x
DO - 10.1111/j.1600-0609.2009.01270.x
M3 - Article
C2 - 19459924
AN - SCOPUS:68849126870
SN - 0902-4441
VL - 83
SP - 258
EP - 260
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 3
ER -