Acute oxalate nephropathy after massive ascorbic acid administration

J. M. Lawton, L. T. Conway, J. T. Crosson, C. L. Smith, P. A. Abraham

Research output: Contribution to journalArticle

Abstract

A single 45-g dose of intravenous ascorbic acid, a metabolic precursor of oxalate, was administered to a patient as adjuvant therapy for primary amyloidosis and the nephrotic syndrome. Acute oliguric renal failure occurred. Postmortem histopathologic examination of renal tissue revealed extensive intratubular deposition of crystalline material, which was confirmed as calcium oxalate by a microincineration technique. There were no extrarenal deposits of calcium oxalate. Plasma oxalate and ascorbic acid concentrations were increased. We conclude that therapy with high-dose ascorbic acid is a potential cause of oxalate nephropathy.

Original languageEnglish (US)
Pages (from-to)950-951
Number of pages2
JournalArchives of Internal Medicine
Volume145
Issue number5
DOIs
StatePublished - Oct 2 1985

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Oxalates
Ascorbic Acid
Calcium Oxalate
Nephrotic Syndrome
Acute Kidney Injury
Autopsy
Kidney
Therapeutics

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Lawton, J. M., Conway, L. T., Crosson, J. T., Smith, C. L., & Abraham, P. A. (1985). Acute oxalate nephropathy after massive ascorbic acid administration. Archives of Internal Medicine, 145(5), 950-951. https://doi.org/10.1001/archinte.145.5.950

Acute oxalate nephropathy after massive ascorbic acid administration. / Lawton, J. M.; Conway, L. T.; Crosson, J. T.; Smith, C. L.; Abraham, P. A.

In: Archives of Internal Medicine, Vol. 145, No. 5, 02.10.1985, p. 950-951.

Research output: Contribution to journalArticle

Lawton, JM, Conway, LT, Crosson, JT, Smith, CL & Abraham, PA 1985, 'Acute oxalate nephropathy after massive ascorbic acid administration', Archives of Internal Medicine, vol. 145, no. 5, pp. 950-951. https://doi.org/10.1001/archinte.145.5.950
Lawton, J. M. ; Conway, L. T. ; Crosson, J. T. ; Smith, C. L. ; Abraham, P. A. / Acute oxalate nephropathy after massive ascorbic acid administration. In: Archives of Internal Medicine. 1985 ; Vol. 145, No. 5. pp. 950-951.
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