Acute Oligoarthritis Associated With Clostridium difficile Pseudomembranous Colitis

Richard P. Lofgren, Lauri M. Tadlock, Ronald D. Soltis

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The abrupt onset of a sterile inflammatory oligoarthritis developed in a patient with active Clostridium difficile pseudomembranous colitis. The arthritis affected a hip and a knee. Leukocyte counts of synovial fluid obtained from the patient’s left hip and knee were elevated. He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. Three other cases of arthritis associated with antibiotic-induced colitis were reviewed. It seems as if treatment of the colitis leads to resolution of the arthritis.

Original languageEnglish (US)
Pages (from-to)617-619
Number of pages3
JournalArchives of Internal Medicine
Issue number3
StatePublished - Mar 1984

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