Acute nonlymphocytic leukemia in patients with nodular lymphoma

Allan J Collins; Clara D. Bloomfield; Bruce A Peterson; Robert W McKenna

doi:10.1002/1097-0142(197710)40:4<1748::AID-CNCR2820400451>3.0.CO;2-2

Acute nonlymphocytic leukemia in patients with nodular lymphoma

Allan J Collins, Clara D. Bloomfield, Bruce A Peterson, Robert W McKenna

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Abstract

Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL‐N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panmyelosis was present with striking morphologic abnormalities in leukocytes, erythrocytes and megakaryocytes. Marrow cytogenetic studies demonstrated abnormalities in all three patients studied. One of three patients treated with intensive chemotherapy obtained a complete remission. When long term survivors with PDL‐N develop increasing anemia and thrombocytopenia, morphologic and cytogenetic marrow examinations are indicated to distinguish progressive lymphoma from therapy‐induced myelosuppression or ANLL.

Original language	English (US)
Pages (from-to)	1748-1754
Number of pages	7
Journal	Cancer
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(197710)40:4<1748::AID-CNCR2820400451>3.0.CO;2-2
State	Published - Oct 1977

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10.1002/1097-0142(197710)40:4<1748::AID-CNCR2820400451>3.0.CO;2-2

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title = "Acute nonlymphocytic leukemia in patients with nodular lymphoma",

abstract = "Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL‐N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panmyelosis was present with striking morphologic abnormalities in leukocytes, erythrocytes and megakaryocytes. Marrow cytogenetic studies demonstrated abnormalities in all three patients studied. One of three patients treated with intensive chemotherapy obtained a complete remission. When long term survivors with PDL‐N develop increasing anemia and thrombocytopenia, morphologic and cytogenetic marrow examinations are indicated to distinguish progressive lymphoma from therapy‐induced myelosuppression or ANLL.",

author = "Collins, {Allan J} and Bloomfield, {Clara D.} and Peterson, {Bruce A} and McKenna, {Robert W}",

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T1 - Acute nonlymphocytic leukemia in patients with nodular lymphoma

AU - Collins, Allan J

AU - Bloomfield, Clara D.

AU - Peterson, Bruce A

AU - McKenna, Robert W

PY - 1977/10

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N2 - Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL‐N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panmyelosis was present with striking morphologic abnormalities in leukocytes, erythrocytes and megakaryocytes. Marrow cytogenetic studies demonstrated abnormalities in all three patients studied. One of three patients treated with intensive chemotherapy obtained a complete remission. When long term survivors with PDL‐N develop increasing anemia and thrombocytopenia, morphologic and cytogenetic marrow examinations are indicated to distinguish progressive lymphoma from therapy‐induced myelosuppression or ANLL.

AB - Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL‐N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panmyelosis was present with striking morphologic abnormalities in leukocytes, erythrocytes and megakaryocytes. Marrow cytogenetic studies demonstrated abnormalities in all three patients studied. One of three patients treated with intensive chemotherapy obtained a complete remission. When long term survivors with PDL‐N develop increasing anemia and thrombocytopenia, morphologic and cytogenetic marrow examinations are indicated to distinguish progressive lymphoma from therapy‐induced myelosuppression or ANLL.

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Acute nonlymphocytic leukemia in patients with nodular lymphoma

Abstract

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