Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Katherine Tarlock; Todd A. Alonzo; Pilar P. Moraleda; Robert B. Gerbing; Susana C. Raimondi; Betsy A. Hirsch; Yaddanapudi Ravindranath; Beverly Lange; William G. Woods; Alan S. Gamis; Soheil Meshinchi

doi:10.1111/bjh.12852

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Katherine Tarlock
, Todd A. Alonzo
, Pilar P. Moraleda
, Robert B. Gerbing
, Susana C. Raimondi
, Betsy A. Hirsch
, Yaddanapudi Ravindranath
, Beverly Lange
, William G. Woods
, Alan S. Gamis
, Soheil Meshinchi

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

Original language	English (US)
Pages (from-to)	254-259
Number of pages	6
Journal	British journal of haematology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1111/bjh.12852
State	Published - Jul 2014

Keywords

Acute myeloid leukaemia
Clinical outcome
FLT3-ITD
Paediatric
T(6; 9)(p23; q34)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bjh.12852

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Tarlock, K., Alonzo, T. A., Moraleda, P. P., Gerbing, R. B., Raimondi, S. C., Hirsch, B. A., Ravindranath, Y., Lange, B., Woods, W. G., Gamis, A. S., & Meshinchi, S. (2014). Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group. British journal of haematology, 166(2), 254-259. https://doi.org/10.1111/bjh.12852

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group. / Tarlock, Katherine; Alonzo, Todd A.; Moraleda, Pilar P. et al.
In: British journal of haematology, Vol. 166, No. 2, 07.2014, p. 254-259.

Research output: Contribution to journal › Article › peer-review

Tarlock, K, Alonzo, TA, Moraleda, PP, Gerbing, RB, Raimondi, SC, Hirsch, BA, Ravindranath, Y, Lange, B, Woods, WG, Gamis, AS & Meshinchi, S 2014, 'Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group', British journal of haematology, vol. 166, no. 2, pp. 254-259. https://doi.org/10.1111/bjh.12852

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title = "Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group",

abstract = "Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40\% and 27\% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.",

keywords = "Acute myeloid leukaemia, Clinical outcome, FLT3-ITD, Paediatric, T(6; 9)(p23; q34)",

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doi = "10.1111/bjh.12852",

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AU - Tarlock, Katherine

AU - Alonzo, Todd A.

AU - Moraleda, Pilar P.

AU - Gerbing, Robert B.

AU - Raimondi, Susana C.

AU - Hirsch, Betsy A.

AU - Ravindranath, Yaddanapudi

AU - Lange, Beverly

AU - Woods, William G.

AU - Gamis, Alan S.

AU - Meshinchi, Soheil

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N2 - Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

AB - Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

KW - Acute myeloid leukaemia

KW - Clinical outcome

KW - FLT3-ITD

KW - Paediatric

KW - T(6; 9)(p23; q34)

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Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Abstract

Keywords

UN SDGs

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