Acute leukemia in six horses (1990–2012)

Emily A. Barrell, Midori Goto Asakawa, M. Julia B. Felippe, Thomas J. Divers, Tracy Stokol

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with >20% bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2–8 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy). Characteristic hemogram findings were bi- or pancytopenia with low blast numbers. Histologic examination revealed extramedullary infiltrates, especially in lymph nodes, spleen, kidney, liver, and lungs. Leukemias were classified as B-cell (n = 3) and acute myeloid leukemia (AML) (n = 3). Tumors in 4 cases expressed multiple lineage markers, which complicated classification. Acute leukemia should be suspected in horses with moderate-to-severe bi- or pancytopenia. Blood smears should be reviewed for neoplastic cells, and bone marrow examination is required for diagnosis. Leukemia classification is best achieved using combined morphologic, cytochemical, and immunophenotyping results.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume29
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

leukemia
Horses
Leukemia
horses
Immunophenotyping
Pancytopenia
bone marrow
Bone Marrow Examination
myeloid leukemia
Lethargy
Acute Myeloid Leukemia
fever
B-lymphocytes
Medical Records
lymph nodes
spleen
B-Lymphocytes
Fever
Spleen
Lymph Nodes

Keywords

  • Acute lymphoblastic or myeloid leukemia
  • equine

Cite this

Acute leukemia in six horses (1990–2012). / Barrell, Emily A.; Asakawa, Midori Goto; Felippe, M. Julia B.; Divers, Thomas J.; Stokol, Tracy.

In: Journal of Veterinary Diagnostic Investigation, Vol. 29, No. 4, 01.07.2017, p. 529-535.

Research output: Contribution to journalArticle

Barrell, EA, Asakawa, MG, Felippe, MJB, Divers, TJ & Stokol, T 2017, 'Acute leukemia in six horses (1990–2012)', Journal of Veterinary Diagnostic Investigation, vol. 29, no. 4, pp. 529-535. https://doi.org/10.1177/1040638717707724
Barrell, Emily A. ; Asakawa, Midori Goto ; Felippe, M. Julia B. ; Divers, Thomas J. ; Stokol, Tracy. / Acute leukemia in six horses (1990–2012). In: Journal of Veterinary Diagnostic Investigation. 2017 ; Vol. 29, No. 4. pp. 529-535.
@article{b5a9c17be8b34f11b1d4f38d59a8a303,
title = "Acute leukemia in six horses (1990–2012)",
abstract = "Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with >20{\%} bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2–8 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy). Characteristic hemogram findings were bi- or pancytopenia with low blast numbers. Histologic examination revealed extramedullary infiltrates, especially in lymph nodes, spleen, kidney, liver, and lungs. Leukemias were classified as B-cell (n = 3) and acute myeloid leukemia (AML) (n = 3). Tumors in 4 cases expressed multiple lineage markers, which complicated classification. Acute leukemia should be suspected in horses with moderate-to-severe bi- or pancytopenia. Blood smears should be reviewed for neoplastic cells, and bone marrow examination is required for diagnosis. Leukemia classification is best achieved using combined morphologic, cytochemical, and immunophenotyping results.",
keywords = "Acute lymphoblastic or myeloid leukemia, equine",
author = "Barrell, {Emily A.} and Asakawa, {Midori Goto} and Felippe, {M. Julia B.} and Divers, {Thomas J.} and Tracy Stokol",
year = "2017",
month = "7",
day = "1",
doi = "10.1177/1040638717707724",
language = "English (US)",
volume = "29",
pages = "529--535",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "4",

}

TY - JOUR

T1 - Acute leukemia in six horses (1990–2012)

AU - Barrell, Emily A.

AU - Asakawa, Midori Goto

AU - Felippe, M. Julia B.

AU - Divers, Thomas J.

AU - Stokol, Tracy

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with >20% bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2–8 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy). Characteristic hemogram findings were bi- or pancytopenia with low blast numbers. Histologic examination revealed extramedullary infiltrates, especially in lymph nodes, spleen, kidney, liver, and lungs. Leukemias were classified as B-cell (n = 3) and acute myeloid leukemia (AML) (n = 3). Tumors in 4 cases expressed multiple lineage markers, which complicated classification. Acute leukemia should be suspected in horses with moderate-to-severe bi- or pancytopenia. Blood smears should be reviewed for neoplastic cells, and bone marrow examination is required for diagnosis. Leukemia classification is best achieved using combined morphologic, cytochemical, and immunophenotyping results.

AB - Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with >20% bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2–8 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy). Characteristic hemogram findings were bi- or pancytopenia with low blast numbers. Histologic examination revealed extramedullary infiltrates, especially in lymph nodes, spleen, kidney, liver, and lungs. Leukemias were classified as B-cell (n = 3) and acute myeloid leukemia (AML) (n = 3). Tumors in 4 cases expressed multiple lineage markers, which complicated classification. Acute leukemia should be suspected in horses with moderate-to-severe bi- or pancytopenia. Blood smears should be reviewed for neoplastic cells, and bone marrow examination is required for diagnosis. Leukemia classification is best achieved using combined morphologic, cytochemical, and immunophenotyping results.

KW - Acute lymphoblastic or myeloid leukemia

KW - equine

UR - http://www.scopus.com/inward/record.url?scp=85021924477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021924477&partnerID=8YFLogxK

U2 - 10.1177/1040638717707724

DO - 10.1177/1040638717707724

M3 - Article

C2 - 28467276

AN - SCOPUS:85021924477

VL - 29

SP - 529

EP - 535

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 4

ER -