Acute leukemia expressing the gamma gene product of the putative second T cell receptor

R. González-Sarmiento; T. W. LeBien; J. G. Bradley; J. M. Greenberg; J. G. Seidman; S. Ang; J. H. Kersey

doi:10.1172/JCI112949

Acute leukemia expressing the gamma gene product of the putative second T cell receptor

R. González-Sarmiento, T. W. LeBien, J. G. Bradley, J. M. Greenberg, J. G. Seidman, S. Ang, J. H. Kersey

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Abstract

Early thymus-derived lymphocytes bearing the Tγ gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2⁺, CD3⁺, CD4^-, CD5⁺, CD7⁺, CD8^-, WT31^- phenotype. These cells were found to have a Tγ gene rearrangement and Tγ transcripts in absence of Tα or Tβ rearrangements or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative Tγ protein.

Original language	English (US)
Pages (from-to)	1281-1284
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	79
Issue number	4
DOIs	https://doi.org/10.1172/JCI112949
State	Published - 1987

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abstract = "Early thymus-derived lymphocytes bearing the Tγ gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have a Tγ gene rearrangement and Tγ transcripts in absence of Tα or Tβ rearrangements or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative Tγ protein.",

author = "R. Gonz{\'a}lez-Sarmiento and LeBien, {T. W.} and Bradley, {J. G.} and Greenberg, {J. M.} and Seidman, {J. G.} and S. Ang and Kersey, {J. H.}",

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T1 - Acute leukemia expressing the gamma gene product of the putative second T cell receptor

AU - González-Sarmiento, R.

AU - LeBien, T. W.

AU - Bradley, J. G.

AU - Greenberg, J. M.

AU - Seidman, J. G.

AU - Ang, S.

AU - Kersey, J. H.

PY - 1987

Y1 - 1987

N2 - Early thymus-derived lymphocytes bearing the Tγ gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have a Tγ gene rearrangement and Tγ transcripts in absence of Tα or Tβ rearrangements or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative Tγ protein.

AB - Early thymus-derived lymphocytes bearing the Tγ gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have a Tγ gene rearrangement and Tγ transcripts in absence of Tα or Tβ rearrangements or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative Tγ protein.

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Acute leukemia expressing the gamma gene product of the putative second T cell receptor

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