Acute kidney injury associated with non-steroidal anti-inflammatory drugs

Nattawat Klomjit, Patompong Ungprasert

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are ones of the commonly prescribed drugs worldwide. They primarily inhibit cyclooxygenase (COX) enzyme which is responsible for conversion of phospholipids to various prostaglandins (PGs). Disruption in PGs production affects the kidneys in several ways, including vasoconstriction that may result in ischemic acute kidney injury (AKI) in at-risk patients. They also impair salt and water excretion, leading to edema and hypertension. Other complications include hyperkalemia, hyponatremia, nephrotic syndrome, acute interstitial nephritis and chronic kidney disease progression. AKI from NSAIDs is usually reversible with favorable prognosis after discontinuation of NSAIDs. Avoidance of NSAIDs exposure is extremely important, especially among high-risk patients.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalEuropean Journal of Internal Medicine
Volume101
DOIs
StatePublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022

Keywords

  • Acute interstitial nephritis
  • Acute kidney injury
  • AIN
  • AKI
  • COX
  • Cyclooxygenase
  • Nephrotic syndrome
  • Non-steroidal anti-inflammatory drugs
  • NSAIDs
  • PGs
  • Prostaglandin
  • Acute Kidney Injury/chemically induced
  • Anti-Inflammatory Agents, Non-Steroidal/adverse effects
  • Cyclooxygenase 2
  • Humans
  • Nephritis, Interstitial/chemically induced
  • Kidney

PubMed: MeSH publication types

  • Review
  • Journal Article

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