Acute Kidney Injury and Sepsis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Worldwide, both acute kidney injury (AKI) and sepsis are significant clinical complications, particularly in critical care patients. Sepsis is an important cause of AKI, and AKI is a common complication of sepsis. Methods: We reviewed the literature, including current practice guidelines, on sepsis-associated AKI. Results: We assessed causes of renal failure, potential mechanisms of sepsis-associated acute kidney injury, current practice guidelines, diagnostic criteria and methods, prevention strategies, treatment options, and outcomes. Conclusion: In patients with sepsis-associated AKI, appropriate fluid resuscitation and maintenance of blood pressure are important to prevent further kidney damage. Despite multiple clinical trials, the mechanisms of sepsis-associated AKI and the best treatment options remain unclear.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalSurgical infections
Issue number2
StatePublished - Feb 1 2018


  • Acute renal failure
  • renal
  • sepsis

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