TY - JOUR
T1 - Acute hospital-induced hyponatremia in children
T2 - A physiologic approach
AU - Holliday, Malcolm A.
AU - Friedman, Aaron L.
AU - Segar, William E.
AU - Chesney, Russell
AU - Finberg, Laurence
PY - 2004/11
Y1 - 2004/11
N2 - Children admitted with acute disease or for surgery incur a significant risk of hyponatremia if even subtle hypovolemia is present and is not corrected be1fore they are given hypotonic saline as maintenance therapy. The risk is exaggerated if maintenance therapy is given in excess of recommendations. This risk is greatly reduced (1) by initially giving children with even subtle hypovolemia, 20 to 40 mL/kg of isotonic saline in 2-4 hours and (2) by correctly calculating maintenance therapy, indexing it to metabolic rate (see Table) and clinical state.
AB - Children admitted with acute disease or for surgery incur a significant risk of hyponatremia if even subtle hypovolemia is present and is not corrected be1fore they are given hypotonic saline as maintenance therapy. The risk is exaggerated if maintenance therapy is given in excess of recommendations. This risk is greatly reduced (1) by initially giving children with even subtle hypovolemia, 20 to 40 mL/kg of isotonic saline in 2-4 hours and (2) by correctly calculating maintenance therapy, indexing it to metabolic rate (see Table) and clinical state.
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U2 - 10.1016/j.jpeds.2004.06.077
DO - 10.1016/j.jpeds.2004.06.077
M3 - Comment/debate
C2 - 15520753
AN - SCOPUS:7444256114
SN - 0022-3476
VL - 145
SP - 584
EP - 587
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -