Acute hospital-induced hyponatremia in children: A physiologic approach

Malcolm A. Holliday, Aaron L. Friedman, William E. Segar, Russell Chesney, Laurence Finberg

Research output: Contribution to journalComment/debatepeer-review

96 Scopus citations


Children admitted with acute disease or for surgery incur a significant risk of hyponatremia if even subtle hypovolemia is present and is not corrected be1fore they are given hypotonic saline as maintenance therapy. The risk is exaggerated if maintenance therapy is given in excess of recommendations. This risk is greatly reduced (1) by initially giving children with even subtle hypovolemia, 20 to 40 mL/kg of isotonic saline in 2-4 hours and (2) by correctly calculating maintenance therapy, indexing it to metabolic rate (see Table) and clinical state.

Original languageEnglish (US)
Pages (from-to)584-587
Number of pages4
JournalJournal of Pediatrics
Issue number5
StatePublished - Nov 2004
Externally publishedYes


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