Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

Joanna M. Joly, Deepak Acharya, Harish Doppalapudi, G. Neal Kay, Chee Paul Lin, William R. Maddox, H. Thomas McElderry, Salpy V. Pamboukian, Vance J. Plumb, Indranee N. Rajapreyar, José A. Tallaj, Takumi Yamada, Vineet Kumar

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.

Original languageEnglish (US)
Pages (from-to)716-718
Number of pages3
JournalJournal of cardiac failure
Issue number10
StatePublished - Oct 2018
Externally publishedYes

Bibliographical note

Funding Information:
Statistical analysis reported in this publication was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health , under award number UL1TR001417 .

Publisher Copyright:
© 2018


  • Hemodynamics
  • biventricular pacing
  • cardiac resynchronization therapy
  • heart failure
  • left ventricular assist device
  • right heart catheterization


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