Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex

Douglas A. Marsteller; Madina R. Gerasimov; Wynne K. Schiffer; Justin M. Geiger; Channing R. Barnett; Jana Schaich Borg; Sabria Scott; Jill Ceccarelli; Nora D. Volkow; Patricia E. Molina; David L. Alexoff; Stephen L. Dewey

doi:10.1016/S0893-133X(02)00288-9

Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex

Douglas A. Marsteller, Madina R. Gerasimov, Wynne K. Schiffer, Justin M. Geiger, Channing R. Barnett, Jana Schaich Borg, Sabria Scott, Jill Ceccarelli, Nora D. Volkow, Patricia E. Molina, David L. Alexoff, Stephen L. Dewey

Neurology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed the present study to investigate the effect of handling stress on catecholaminergic responsivity following an acute methylphenidate (MP, Ritalin) challenge in the medial prefrontal cortex (mPFC). Norepinephrine (NE) and dopamine (DA) levels were simultaneously measured in 15-min samples of PFC dialysate using HPLC coupled with electrochemical detection. Sprague-Dawley rats were handled for 15 min, which produced an increase from basal extracellular DA and NE levels. Handling stress attenuates the DA response when administered 2 h prior to IP MP, whereas handling stress enhances the DA response when administered simultaneously with IG MP. These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge.

Original language	English (US)
Pages (from-to)	163-170
Number of pages	8
Journal	Neuropsychopharmacology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/S0893-133X(02)00288-9
State	Published - 2002

Bibliographical note

Funding Information:
This research was carried out at Brookhaven National Laboratory under contract with the U.S. Department of Energy Office of Biological and Environmental Research (USDOE/OBER DE-AC02-98CH10886), and by the National Institutes of Mental Health (NIMH MH49165 and NIMH R2955155) and the National Institute on Drug Abuse (5RO-DA06278 and DA09490).

Keywords

Dopamine
Handling stress
Medial prefrontal cortex
Methylphenidate
Microdialysis
Norepinephrine

Publisher link

10.1016/S0893-133X(02)00288-9

Find It

Find It at U of M Libraries

Cite this

Marsteller, D. A., Gerasimov, M. R., Schiffer, W. K., Geiger, J. M., Barnett, C. R., Borg, J. S., Scott, S., Ceccarelli, J., Volkow, N. D., Molina, P. E., Alexoff, D. L., & Dewey, S. L. (2002). Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex. Neuropsychopharmacology, 27(2), 163-170. https://doi.org/10.1016/S0893-133X(02)00288-9

Marsteller, DA, Gerasimov, MR, Schiffer, WK, Geiger, JM, Barnett, CR, Borg, JS, Scott, S, Ceccarelli, J, Volkow, ND, Molina, PE, Alexoff, DL & Dewey, SL 2002, 'Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex', Neuropsychopharmacology, vol. 27, no. 2, pp. 163-170. https://doi.org/10.1016/S0893-133X(02)00288-9

@article{8a9d55958803485db244d5f275c28c89,

title = "Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex",

abstract = "Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed the present study to investigate the effect of handling stress on catecholaminergic responsivity following an acute methylphenidate (MP, Ritalin) challenge in the medial prefrontal cortex (mPFC). Norepinephrine (NE) and dopamine (DA) levels were simultaneously measured in 15-min samples of PFC dialysate using HPLC coupled with electrochemical detection. Sprague-Dawley rats were handled for 15 min, which produced an increase from basal extracellular DA and NE levels. Handling stress attenuates the DA response when administered 2 h prior to IP MP, whereas handling stress enhances the DA response when administered simultaneously with IG MP. These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge.",

keywords = "Dopamine, Handling stress, Medial prefrontal cortex, Methylphenidate, Microdialysis, Norepinephrine",

author = "Marsteller, {Douglas A.} and Gerasimov, {Madina R.} and Schiffer, {Wynne K.} and Geiger, {Justin M.} and Barnett, {Channing R.} and Borg, {Jana Schaich} and Sabria Scott and Jill Ceccarelli and Volkow, {Nora D.} and Molina, {Patricia E.} and Alexoff, {David L.} and Dewey, {Stephen L.}",

note = "Funding Information: This research was carried out at Brookhaven National Laboratory under contract with the U.S. Department of Energy Office of Biological and Environmental Research (USDOE/OBER DE-AC02-98CH10886), and by the National Institutes of Mental Health (NIMH MH49165 and NIMH R2955155) and the National Institute on Drug Abuse (5RO-DA06278 and DA09490).",

year = "2002",

doi = "10.1016/S0893-133X(02)00288-9",

language = "English (US)",

volume = "27",

pages = "163--170",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Springer Nature",

number = "2",

}

TY - JOUR

T1 - Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex

AU - Marsteller, Douglas A.

AU - Gerasimov, Madina R.

AU - Schiffer, Wynne K.

AU - Geiger, Justin M.

AU - Barnett, Channing R.

AU - Borg, Jana Schaich

AU - Scott, Sabria

AU - Ceccarelli, Jill

AU - Volkow, Nora D.

AU - Molina, Patricia E.

AU - Alexoff, David L.

AU - Dewey, Stephen L.

N1 - Funding Information: This research was carried out at Brookhaven National Laboratory under contract with the U.S. Department of Energy Office of Biological and Environmental Research (USDOE/OBER DE-AC02-98CH10886), and by the National Institutes of Mental Health (NIMH MH49165 and NIMH R2955155) and the National Institute on Drug Abuse (5RO-DA06278 and DA09490).

PY - 2002

Y1 - 2002

N2 - Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed the present study to investigate the effect of handling stress on catecholaminergic responsivity following an acute methylphenidate (MP, Ritalin) challenge in the medial prefrontal cortex (mPFC). Norepinephrine (NE) and dopamine (DA) levels were simultaneously measured in 15-min samples of PFC dialysate using HPLC coupled with electrochemical detection. Sprague-Dawley rats were handled for 15 min, which produced an increase from basal extracellular DA and NE levels. Handling stress attenuates the DA response when administered 2 h prior to IP MP, whereas handling stress enhances the DA response when administered simultaneously with IG MP. These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge.

AB - Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed the present study to investigate the effect of handling stress on catecholaminergic responsivity following an acute methylphenidate (MP, Ritalin) challenge in the medial prefrontal cortex (mPFC). Norepinephrine (NE) and dopamine (DA) levels were simultaneously measured in 15-min samples of PFC dialysate using HPLC coupled with electrochemical detection. Sprague-Dawley rats were handled for 15 min, which produced an increase from basal extracellular DA and NE levels. Handling stress attenuates the DA response when administered 2 h prior to IP MP, whereas handling stress enhances the DA response when administered simultaneously with IG MP. These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge.

KW - Dopamine

KW - Handling stress

KW - Medial prefrontal cortex

KW - Methylphenidate

KW - Microdialysis

KW - Norepinephrine

UR - http://www.scopus.com/inward/record.url?scp=0036294632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036294632&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(02)00288-9

DO - 10.1016/S0893-133X(02)00288-9

M3 - Article

C2 - 12093590

AN - SCOPUS:0036294632

SN - 0893-133X

VL - 27

SP - 163

EP - 170

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 2

ER -

Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this