TY - JOUR
T1 - Acute graft-versus-host disease
T2 - From the bench to the bedside
AU - Socié, Gerard
AU - Blazar, Bruce R.
PY - 2009/11/12
Y1 - 2009/11/12
N2 - During the past decade, progress in basic immunology has been impressive. In parallel, whereas our understanding of the pathophysiology of acute graft-versus-host disease (GVHD) has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of acute GVHD has been gleaned from preclinical models and far less from correlations with clinical observations or therapeutic interventions. In this review, we summarize some of the major advances in GVHD pathophysiology, including the translation of these from the bench to the bedside, and discuss preclinical approaches that warrant further exploration in the clinic.
AB - During the past decade, progress in basic immunology has been impressive. In parallel, whereas our understanding of the pathophysiology of acute graft-versus-host disease (GVHD) has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of acute GVHD has been gleaned from preclinical models and far less from correlations with clinical observations or therapeutic interventions. In this review, we summarize some of the major advances in GVHD pathophysiology, including the translation of these from the bench to the bedside, and discuss preclinical approaches that warrant further exploration in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=73349118783&partnerID=8YFLogxK
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U2 - 10.1182/blood-2009-06-204669
DO - 10.1182/blood-2009-06-204669
M3 - Article
C2 - 19713461
AN - SCOPUS:73349118783
SN - 0006-4971
VL - 114
SP - 4327
EP - 4336
JO - Blood
JF - Blood
IS - 20
ER -