Acute graft-versus-host disease: From the bench to the bedside

Gerard Socié, Bruce R. Blazar

Research output: Contribution to journalArticle

195 Scopus citations

Abstract

During the past decade, progress in basic immunology has been impressive. In parallel, whereas our understanding of the pathophysiology of acute graft-versus-host disease (GVHD) has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of acute GVHD has been gleaned from preclinical models and far less from correlations with clinical observations or therapeutic interventions. In this review, we summarize some of the major advances in GVHD pathophysiology, including the translation of these from the bench to the bedside, and discuss preclinical approaches that warrant further exploration in the clinic.

Original languageEnglish (US)
Pages (from-to)4327-4336
Number of pages10
JournalBlood
Volume114
Issue number20
DOIs
StatePublished - Nov 12 2009

Fingerprint Dive into the research topics of 'Acute graft-versus-host disease: From the bench to the bedside'. Together they form a unique fingerprint.

  • Cite this