Acute graft-versus-host disease - Biologic process, prevention, and therapy

Robert Zeiser, Bruce R. Blazar

Research output: Contribution to journalReview article

170 Scopus citations

Abstract

The allogeneic transplantation of hematopoietic cells is a well-established treatment for hematologic diseases that cannot be cured with conventional treatments.1 More than 1 million hematopoietic-cell transplantations have been performed, of which 40% were allogeneic.2 The most common life-threatening complication is graft-versus-host disease (GVHD), which occurs when immunocompetent T cells in the donated tissue (the graft) recognize the recipient (the host) as foreign. The resulting immune response activates donor T cells to gain cytolytic capacity and to then attack the recipient to eliminate foreign antigen-bearing cells. The two main clinical presentations are acute GVHD and chronic GVHD. This review focuses on acute GVHD.

Original languageEnglish (US)
Pages (from-to)2167-2179
Number of pages13
JournalNew England Journal of Medicine
Volume377
Issue number22
DOIs
StatePublished - Nov 30 2017

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