Acute changes in thyroid function in patients treated with radioactive iodine

RexB Shafer, FrankQ Nuttall

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Serum triiodothyronine (T3) and thyroxine (T4) were measured in thirteen unselected hyperthyroid patients before and at frequent intervals after iodine-131 treatment. There was an abrupt rise in T3 from a pretreatment mean of 250 ng/100 ml to a maximum of 365 ng/100 ml at 24 hours. Total T4 rose from a mean of 18·7 μg/100 ml to a maximum of 22·3 μg/100 ml at 24-48 hours. These findings may explain why an occasional patient develops acute thyroid crisis after radioiodine treatment.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalThe Lancet
Issue number7936
StatePublished - Oct 4 1975

Bibliographical note

Funding Information:
Sfstance, Dr D. Burnett, of the Clinical Biochemistry Department, St. Albans, for measurement of phenytoin levels, and the National Fund for Research into Crippling Diseases for financial support.

Copyright 2018 Elsevier B.V., All rights reserved.


Dive into the research topics of 'Acute changes in thyroid function in patients treated with radioactive iodine'. Together they form a unique fingerprint.

Cite this