TY - JOUR
T1 - Acute and Late Bartonella henselae Murine Model Infection
AU - Da Silva, Marilene Neves
AU - Vieira-Damiani, Gislaine
AU - Ericson, Marna Elise
AU - Gupta, Kalpna
AU - De Almeida, Amanda Roberta
AU - Drummond, Marina Rovani
AU - Soares, Tania Cristina Benetti
AU - Lania, Bruno Grosselli
AU - Gilioli, Rovilson
AU - Velho, Paulo Eduardo Neves Ferreira
N1 - Publisher Copyright:
© Copyright 2017, Mary Ann Liebert, Inc. 2017.
PY - 2017/3
Y1 - 2017/3
N2 - Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.
AB - Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.
UR - https://www.scopus.com/pages/publications/85014085890
UR - https://www.scopus.com/inward/citedby.url?scp=85014085890&partnerID=8YFLogxK
U2 - 10.1089/vbz.2016.2007
DO - 10.1089/vbz.2016.2007
M3 - Article
C2 - 28165916
AN - SCOPUS:85014085890
SN - 1530-3667
VL - 17
SP - 206
EP - 208
JO - Vector-Borne and Zoonotic Diseases
JF - Vector-Borne and Zoonotic Diseases
IS - 3
ER -