Acute abstinence effects following smoked cocaine administration in humans

Susan Dudish-Poulsen, Dorothy K Hatsukami

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Acute abstinence symptomatology following multiple deliveries of smoked cocaine was examined. Twelve crack cocaine users (male and female) participated in an inpatient study. Participants smoked 7 deliveries of cocaine on each of 4 experimental days, with each participant being exposed twice to 2 dose sizes of cocaine (0.40 vs. 0.07 mg/kg 'placebo'). Symptoms of cocaine abstinence were measured for 6 hr following cocaine administration and again the following morning. Participants reported feeling increased craving, anxiety, and uncertainty 30 min after the 7th delivery of 0.40 mg/kg cocaine, when cocaine plasma levels were still on the descending curve. It is not clear whether these were true abstinence effects or were due to residual effects of cocaine. No significant differences were found at subsequent abstinence-assessment points. These data indicate that acute abstinence effects from smoked cocaine in a laboratory setting may be minimal.

Original languageEnglish (US)
Pages (from-to)472-482
Number of pages11
JournalExperimental and Clinical Psychopharmacology
Issue number4
StatePublished - 2000


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