Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Alice Chen; Kenneth P. Smith; Betsy A. Whitfield; Paola C. Zucchi; Todd M. Lasco; Tiffany E. Bias; James E. Kirby; Elizabeth B. Hirsch

doi:10.1016/j.diagmicrobio.2017.05.004

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Alice Chen
, Kenneth P. Smith
, Betsy A. Whitfield
, Paola C. Zucchi
, Todd M. Lasco
, Tiffany E. Bias
, James E. Kirby
, Elizabeth B. Hirsch

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).

Original language	English (US)
Pages (from-to)	365-367
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	88
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2017.05.004
State	Published - Aug 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Extended-spectrum beta-lactamase
KPC
Multidrug resistance
Resistant
Tetracycline

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10.1016/j.diagmicrobio.2017.05.004

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Chen, A., Smith, K. P., Whitfield, B. A., Zucchi, P. C., Lasco, T. M., Bias, T. E., Kirby, J. E., & Hirsch, E. B. (2017). Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline. Diagnostic Microbiology and Infectious Disease, 88(4), 365-367. https://doi.org/10.1016/j.diagmicrobio.2017.05.004

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline. / Chen, Alice; Smith, Kenneth P.; Whitfield, Betsy A. et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 88, No. 4, 08.2017, p. 365-367.

Research output: Contribution to journal › Article › peer-review

Chen, A, Smith, KP, Whitfield, BA, Zucchi, PC, Lasco, TM, Bias, TE, Kirby, JE & Hirsch, EB 2017, 'Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline', Diagnostic Microbiology and Infectious Disease, vol. 88, no. 4, pp. 365-367. https://doi.org/10.1016/j.diagmicrobio.2017.05.004

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title = "Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline",

abstract = "We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26\%) or intermediate (26\%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71\% FDA vs. 20\% EUCAST) followed by minocycline (14\%) and then doxycycline (6\%).",

keywords = "Extended-spectrum beta-lactamase, KPC, Multidrug resistance, Resistant, Tetracycline",

author = "Alice Chen and Smith, \{Kenneth P.\} and Whitfield, \{Betsy A.\} and Zucchi, \{Paola C.\} and Lasco, \{Todd M.\} and Bias, \{Tiffany E.\} and Kirby, \{James E.\} and Hirsch, \{Elizabeth B.\}",

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AU - Zucchi, Paola C.

AU - Lasco, Todd M.

AU - Bias, Tiffany E.

AU - Kirby, James E.

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KW - Multidrug resistance

KW - Resistant

KW - Tetracycline

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Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Abstract

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Keywords

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