Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Alice Chen; Kenneth P. Smith; Betsy A. Whitfield; Paola C. Zucchi; Todd M. Lasco; Tiffany E. Bias; James E. Kirby; Elizabeth B. Hirsch

doi:10.1016/j.diagmicrobio.2017.05.004

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Alice Chen, Kenneth P. Smith, Betsy A. Whitfield, Paola C. Zucchi, Todd M. Lasco, Tiffany E. Bias, James E. Kirby, Elizabeth B. Hirsch

Experimental and Clinical Pharmacology

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9 Scopus citations

Abstract

We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).

Original language	English (US)
Pages (from-to)	365-367
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	88
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2017.05.004
State	Published - Aug 2017

Keywords

Extended-spectrum beta-lactamase
KPC
Multidrug resistance
Resistant
Tetracycline

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2017.05.004

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Chen, A., Smith, K. P., Whitfield, B. A., Zucchi, P. C., Lasco, T. M., Bias, T. E., Kirby, J. E., & Hirsch, E. B. (2017). Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline. Diagnostic Microbiology and Infectious Disease, 88(4), 365-367. https://doi.org/10.1016/j.diagmicrobio.2017.05.004

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline. / Chen, Alice; Smith, Kenneth P.; Whitfield, Betsy A. et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 88, No. 4, 08.2017, p. 365-367.

Research output: Contribution to journal › Article › peer-review

Chen, A, Smith, KP, Whitfield, BA, Zucchi, PC, Lasco, TM, Bias, TE, Kirby, JE & Hirsch, EB 2017, 'Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline', Diagnostic Microbiology and Infectious Disease, vol. 88, no. 4, pp. 365-367. https://doi.org/10.1016/j.diagmicrobio.2017.05.004

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abstract = "We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).",

keywords = "Extended-spectrum beta-lactamase, KPC, Multidrug resistance, Resistant, Tetracycline",

author = "Alice Chen and Smith, {Kenneth P.} and Whitfield, {Betsy A.} and Zucchi, {Paola C.} and Lasco, {Todd M.} and Bias, {Tiffany E.} and Kirby, {James E.} and Hirsch, {Elizabeth B.}",

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AU - Zucchi, Paola C.

AU - Lasco, Todd M.

AU - Bias, Tiffany E.

AU - Kirby, James E.

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AB - We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).

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Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Abstract

Keywords

UN SDGs

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