Abstract
Background: Structural determinants of ADAM17 substrate specificity are unknown. Results: ADAM17 activity affected by noncatalytic domains and secondary structure of substrates. Conclusion: Noncatalytic domains and substrate conformation are potentially the key structural elements that determine ADAM17 specificity. Significance: Understanding interaction of ADAM17 with its substrates will assist in discoveryADAMisoform-and substratespecific inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22871-22879 |
| Number of pages | 9 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 31 |
| DOIs | |
| State | Published - Aug 2 2013 |
| Externally published | Yes |
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