Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors

Sunan Fang; A. E. Takemori; Philip S Portoghese

doi:10.1021/jm00376a026

Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors

Sunan Fang, A. E. Takemori, Philip S Portoghese

Medicinal Chemistry

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Abstract

Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.

Original language	English (US)
Pages (from-to)	1361-1363
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	27
Issue number	10
DOIs	https://doi.org/10.1021/jm00376a026
State	Published - Dec 1984

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title = "Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors",

abstract = "Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.",

author = "Sunan Fang and Takemori, {A. E.} and Portoghese, {Philip S}",

year = "1984",

month = dec,

doi = "10.1021/jm00376a026",

language = "English (US)",

volume = "27",

pages = "1361--1363",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "10",

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T1 - Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors

AU - Fang, Sunan

AU - Takemori, A. E.

AU - Portoghese, Philip S

PY - 1984/12

Y1 - 1984/12

N2 - Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.

AB - Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.

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DO - 10.1021/jm00376a026

M3 - Article

C2 - 6207298

AN - SCOPUS:0021222158

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EP - 1363

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 10

ER -

Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors

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