Activities of Morphinone and N-(Cyclopropylmethyl)normorphinone at Opioid Receptors

Sunan Fang, A. E. Takemori, Philip S Portoghese

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.

Original languageEnglish (US)
Pages (from-to)1361-1363
Number of pages3
JournalJournal of medicinal chemistry
Volume27
Issue number10
DOIs
StatePublished - Dec 1984

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