Active interfacial shear microrheology of aging protein films

Prajnaparamita Dhar, Yanyan Cao, Thomas M. Fischer, J. A. Zasadzinski

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


The magnetically driven rotation of 300 nm diameter rods shows the surface viscosity of albumin at an air-water interface increases from 10-9 to 10-5Ns/m over 2 h while the surface pressure saturates in minutes. The increase in surface viscosity is not accompanied by a corresponding increase in elasticity, suggesting that the protein film anneals with time, resulting in a more densely packed film leading to increased resistance to shear. The nanometer dimensions of the rods provide the same sensitivity as passive microrheology with an improved ability to measure more viscous films.

Original languageEnglish (US)
Article number016001
JournalPhysical review letters
Issue number1
StatePublished - Jan 4 2010


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