Active compression garment prevents tilt-induced orthostatic tachycardia in humans

Kevin L. Kelly, Christopher P. Johnson, Lucy E. Dunne, Brad Holschuh, Michael Joyner, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Compression garments are used by patients with lower extremity edema to help regulate fluid distribution and to prevent orthostatic symptoms. Current compression stockings are often reported as uncomfortable and adherence is poor. The current study was conducted to assess the efficacy of a novel active compression garment on healthy individuals undergoing 60-degree head-up tilts for 10 min to induce venous pooling and subsequent physiological responses. During tilts while garments were on, participants’ absolute change in heart rate relative to baseline was lower (16.7 ± 8.7 BPM) compared to control (20.9 ± 11.47 BPM, P = 0.002). There were no differences in changes in mean arterial blood pressure between conditions (P = 0.303). One participant had a pre-syncopal event which occurred during a tilt without garments. This participant did not experience pre-syncopal symptoms with the garments on. All together, these data suggest that a novel active compression garment is capable of blunting increases in heart rate during head-up tilt. While untested thus far in patient populations, these garments may prove efficacious in preventing orthostatic intolerance.

Original languageEnglish (US)
Article numbere14050
JournalPhysiological Reports
Issue number7
StatePublished - Apr 2019

Bibliographical note

Funding Information:
Funding for this study was provided by the Minnesota Partnership for Biotechnology and Medical Genomics, grant number MNP #15.19. This publication was made possible by CTSA Grant Number TL1TR002380 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH.

Publisher Copyright:
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.


  • Compression garment
  • orthostatic intolerance
  • tilt test


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