Activation of polyphosphoinositide hydrolysis in T cells by H-2 alloantigen but not MLS determinants

Anne M. O'Rourke, Matthew F. Mescher, Susan R. Webb

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Murine minor lymphocyte-stimulating (Mls) determinants are cell surface antigens that stimulate strong primary T cell responses; the responding T cells display restricted T cell receptor (TCR) Vp gene usage. Interaction of T cells with mitogens or major histocompatibility complex (MHC) antigens activated the polyphosphoinositide (PI) signaling pathway, but this pathway was not triggered by Mls recognition. However, interleukin-2 (IL-2) secretion and proliferation to all three stimuli were comparable. Thus, although recognition of both allo-H-2 and Mls determinants is thought to be mediated by the TCR, these antigens appear to elicit biochemically distinct signal transduction pathways.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalScience
Volume249
Issue number4965
DOIs
StatePublished - Jan 1 1990

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