Activation of human CD4+CD45RA+ T cells by chrysotile asbestos in vitro

K. Kinugawa, A. Ueki, Masahide Yamaguchi, Yoshiki Watanabe, Yasuhiko Kawakami, Fuminori Hyodoh, Hirobumi Tsushima

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Chrysotile asbestos stimulates T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated after incubation with chrysotile asbestos in vitro temporatily. The percentage of CD4+CD45RA+ cells and mean fluorescence intensity in CD4 or CD45RA decreased after incubation with asbestos and returned to the original level after 24 h of incubation, which suggests that chrysotile asbestos activates CD4+CD45RA+ cells. No change was observed in CD29 expression. An increased percentage of lL-2R positive cells and an elevated intracellular Ca++ level were also indicative of the activation of PBMC by chrysotile asbestos.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalCancer Letters
Volume66
Issue number2
DOIs
StatePublished - Sep 30 1992

Keywords

  • CD4
  • CD45RA
  • asbestos

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