Activation of guanylate cyclase and inhibition of adenylate cyclase by cytotoxic preparations from marine sponges of Haliclona genus

Pushkaraj J. Lad; John W. Brown; W. Thomas Shier

doi:10.1016/0006-291X(78)91169-5

Activation of guanylate cyclase and inhibition of adenylate cyclase by cytotoxic preparations from marine sponges of Haliclona genus

Pushkaraj J. Lad, John W. Brown, W. Thomas Shier

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Of seven marine sponges tested only two, Haliclona viridis and Haliclona rubens, yielded preparations that activated rat heart microsomal guanylate cyclase and exhibited direct hemolytic activity. These two preparations also inhibited basal and fluoride-activated adenylate cyclase in rat heart microsomes and glucagon-stimulated adenylate cyclase in rat liver plasma membranes. Hemolytic activity co-purified with nucleotide cyclase-modulating activity during a standard lipid fractionation procedure. This fraction was cytotoxic to 3T3-4a Swiss mouse fibroblasts.

Original language	English (US)
Pages (from-to)	1472-1479
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	85
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(78)91169-5
State	Published - Dec 29 1978

Bibliographical note

Funding Information:
and Dr. Robert Work for their of sponges and Dr. G. Yogeeswaran for was supported in part by USPHS Grant CA and a grant from the Cystic Fibrosis

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10.1016/0006-291X(78)91169-5

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title = "Activation of guanylate cyclase and inhibition of adenylate cyclase by cytotoxic preparations from marine sponges of Haliclona genus",

abstract = "Of seven marine sponges tested only two, Haliclona viridis and Haliclona rubens, yielded preparations that activated rat heart microsomal guanylate cyclase and exhibited direct hemolytic activity. These two preparations also inhibited basal and fluoride-activated adenylate cyclase in rat heart microsomes and glucagon-stimulated adenylate cyclase in rat liver plasma membranes. Hemolytic activity co-purified with nucleotide cyclase-modulating activity during a standard lipid fractionation procedure. This fraction was cytotoxic to 3T3-4a Swiss mouse fibroblasts.",

author = "Lad, {Pushkaraj J.} and Brown, {John W.} and Shier, {W. Thomas}",

note = "Funding Information: and Dr. Robert Work for their of sponges and Dr. G. Yogeeswaran for was supported in part by USPHS Grant CA and a grant from the Cystic Fibrosis",

year = "1978",

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T1 - Activation of guanylate cyclase and inhibition of adenylate cyclase by cytotoxic preparations from marine sponges of Haliclona genus

AU - Lad, Pushkaraj J.

AU - Brown, John W.

AU - Shier, W. Thomas

N1 - Funding Information: and Dr. Robert Work for their of sponges and Dr. G. Yogeeswaran for was supported in part by USPHS Grant CA and a grant from the Cystic Fibrosis

PY - 1978/12/29

Y1 - 1978/12/29

N2 - Of seven marine sponges tested only two, Haliclona viridis and Haliclona rubens, yielded preparations that activated rat heart microsomal guanylate cyclase and exhibited direct hemolytic activity. These two preparations also inhibited basal and fluoride-activated adenylate cyclase in rat heart microsomes and glucagon-stimulated adenylate cyclase in rat liver plasma membranes. Hemolytic activity co-purified with nucleotide cyclase-modulating activity during a standard lipid fractionation procedure. This fraction was cytotoxic to 3T3-4a Swiss mouse fibroblasts.

AB - Of seven marine sponges tested only two, Haliclona viridis and Haliclona rubens, yielded preparations that activated rat heart microsomal guanylate cyclase and exhibited direct hemolytic activity. These two preparations also inhibited basal and fluoride-activated adenylate cyclase in rat heart microsomes and glucagon-stimulated adenylate cyclase in rat liver plasma membranes. Hemolytic activity co-purified with nucleotide cyclase-modulating activity during a standard lipid fractionation procedure. This fraction was cytotoxic to 3T3-4a Swiss mouse fibroblasts.

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ER -

Activation of guanylate cyclase and inhibition of adenylate cyclase by cytotoxic preparations from marine sponges of Haliclona genus

Abstract

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