Of seven marine sponges tested only two, Haliclona viridis and Haliclona rubens, yielded preparations that activated rat heart microsomal guanylate cyclase and exhibited direct hemolytic activity. These two preparations also inhibited basal and fluoride-activated adenylate cyclase in rat heart microsomes and glucagon-stimulated adenylate cyclase in rat liver plasma membranes. Hemolytic activity co-purified with nucleotide cyclase-modulating activity during a standard lipid fractionation procedure. This fraction was cytotoxic to 3T3-4a Swiss mouse fibroblasts.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Dec 29 1978|
Bibliographical noteFunding Information:
and Dr. Robert Work for their of sponges and Dr. G. Yogeeswaran for was supported in part by USPHS Grant CA and a grant from the Cystic Fibrosis