Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation

Hiroki Imbe; Akihisa Kimura; Keiichiro Okamoto; Tomohiro Donishi; Fumiko Aikawa; Emiko Senba; Yasuhiko Tamai

doi:10.1016/j.brainres.2007.10.075

Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation

Hiroki Imbe, Akihisa Kimura, Keiichiro Okamoto, Tomohiro Donishi, Fumiko Aikawa, Emiko Senba, Yasuhiko Tamai

Basic Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat. Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw. The U0126 microinjection also attenuated thermal hyperalgesia in the ipsilateral hindpaw at 24 h after CFA injection. The ipsilateral paw withdrawal latency in the U0126 group (67.9% ± 5.3% vs. baseline, n = 7) was significantly longer than that in the control group (52.0% ± 3.6% vs. baseline, n = 8). These findings suggest that activation of ERK in the RVM contributes to thermal hyperalgesia during peripheral inflammation.

Original language	English (US)
Pages (from-to)	103-110
Number of pages	8
Journal	Brain Research
Volume	1187
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2007.10.075
State	Published - Jan 2 2008

Bibliographical note

Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research (C) from The Ministry of Education, Culture, Sports, Science and Technology (18613021).

Keywords

Descending system
ERK
Hyperalgesia
Inflammation

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10.1016/j.brainres.2007.10.075

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title = "Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation",

abstract = "We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat. Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw. The U0126 microinjection also attenuated thermal hyperalgesia in the ipsilateral hindpaw at 24 h after CFA injection. The ipsilateral paw withdrawal latency in the U0126 group (67.9% ± 5.3% vs. baseline, n = 7) was significantly longer than that in the control group (52.0% ± 3.6% vs. baseline, n = 8). These findings suggest that activation of ERK in the RVM contributes to thermal hyperalgesia during peripheral inflammation.",

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author = "Hiroki Imbe and Akihisa Kimura and Keiichiro Okamoto and Tomohiro Donishi and Fumiko Aikawa and Emiko Senba and Yasuhiko Tamai",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research (C) from The Ministry of Education, Culture, Sports, Science and Technology (18613021).",

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AU - Imbe, Hiroki

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AU - Okamoto, Keiichiro

AU - Donishi, Tomohiro

AU - Aikawa, Fumiko

AU - Senba, Emiko

AU - Tamai, Yasuhiko

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research (C) from The Ministry of Education, Culture, Sports, Science and Technology (18613021).

PY - 2008/1/2

Y1 - 2008/1/2

N2 - We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat. Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw. The U0126 microinjection also attenuated thermal hyperalgesia in the ipsilateral hindpaw at 24 h after CFA injection. The ipsilateral paw withdrawal latency in the U0126 group (67.9% ± 5.3% vs. baseline, n = 7) was significantly longer than that in the control group (52.0% ± 3.6% vs. baseline, n = 8). These findings suggest that activation of ERK in the RVM contributes to thermal hyperalgesia during peripheral inflammation.

AB - We have previously shown that the extracellular signal-regulated kinase (ERK) is activated in the rostral ventromedial medulla (RVM) during peripheral inflammation. In the present study, the relationship between ERK signaling in the RVM and pain hypersensitivity was investigated in the rat. Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw. The U0126 microinjection also attenuated thermal hyperalgesia in the ipsilateral hindpaw at 24 h after CFA injection. The ipsilateral paw withdrawal latency in the U0126 group (67.9% ± 5.3% vs. baseline, n = 7) was significantly longer than that in the control group (52.0% ± 3.6% vs. baseline, n = 8). These findings suggest that activation of ERK in the RVM contributes to thermal hyperalgesia during peripheral inflammation.

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Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation

Abstract

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