Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors

Matthew F. Mescher, Flavia E. Popescu, Michael Gerner, Chris D. Hammerbeck, Julie M. Curtsinger

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalSeminars in Cancer Biology
Volume17
Issue number4
DOIs
StatePublished - Aug 1 2007

Keywords

  • Anergy
  • CD8 T lymphocyte
  • Tolerance
  • Tumor

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