Action of N,N'-diphenyl-p-phenylenediamine in Tocopherol Deficiency Diseases

H. H. Draper, A. S. Csallany

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Administration of DPPD to growing rabbits and rats fed a Vit. E-low diet does not modify rate of depletion of vitamin from the liver. Tocopherol content of skeletal muscle was essentially unaffected by dietary restriction. DPPD was as effective as α-tocopherol, at level administered, in bringing about a remission of muscular dystrophy and creatinuria in rabbits maintained on diet devoid of tocopherols. Ability of DPPD to partially regenerate sterile female rats maintained on Vit. E-free diet was confirmed. These findings indicate that the effectiveness of DPPD as a substitute for Vit. E is not due to conservation of the vitamin in tissues or to the presence of residual tocopherols in the diet.

Original languageEnglish (US)
Pages (from-to)739-742
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume99
Issue number3
DOIs
StatePublished - Jan 1 1958

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Deficiency Diseases
Tocopherols
Nutrition
Diet
Vitamins
Rats
Rabbits
Muscular Dystrophies
Liver
Muscle
Conservation
Skeletal Muscle
Tissue
N,N'-diphenyl-4-phenylenediamine

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Action of N,N'-diphenyl-p-phenylenediamine in Tocopherol Deficiency Diseases. / Draper, H. H.; Csallany, A. S.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 99, No. 3, 01.01.1958, p. 739-742.

Research output: Contribution to journalArticle

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