Action of N,N'-diphenyl-p-phenylenediamine in Tocopherol Deficiency Diseases

H. H. Draper, A. S. Csallany

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18 Scopus citations


Administration of DPPD to growing rabbits and rats fed a Vit. E-low diet does not modify rate of depletion of vitamin from the liver. Tocopherol content of skeletal muscle was essentially unaffected by dietary restriction. DPPD was as effective as α-tocopherol, at level administered, in bringing about a remission of muscular dystrophy and creatinuria in rabbits maintained on diet devoid of tocopherols. Ability of DPPD to partially regenerate sterile female rats maintained on Vit. E-free diet was confirmed. These findings indicate that the effectiveness of DPPD as a substitute for Vit. E is not due to conservation of the vitamin in tissues or to the presence of residual tocopherols in the diet.

Original languageEnglish (US)
Pages (from-to)739-742
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Dec 1958

Bibliographical note

Funding Information:
This investigation was supported by grant from Muscular Dystrophy Assns. of America. Vitamins were kindly supplied by Merck, Sharpe and Dohme, Rahway, N. J. 12 1958 99 3 739 742


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