Administration of DPPD to growing rabbits and rats fed a Vit. E-low diet does not modify rate of depletion of vitamin from the liver. Tocopherol content of skeletal muscle was essentially unaffected by dietary restriction. DPPD was as effective as α-tocopherol, at level administered, in bringing about a remission of muscular dystrophy and creatinuria in rabbits maintained on diet devoid of tocopherols. Ability of DPPD to partially regenerate sterile female rats maintained on Vit. E-free diet was confirmed. These findings indicate that the effectiveness of DPPD as a substitute for Vit. E is not due to conservation of the vitamin in tissues or to the presence of residual tocopherols in the diet.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Dec 1958|
Bibliographical noteFunding Information:
This investigation was supported by grant from Muscular Dystrophy Assns. of America. Vitamins were kindly supplied by Merck, Sharpe and Dohme, Rahway, N. J. 12 1958 99 3 739 742