Abstract
The actin cytoskeleton contributes directly or indirectly to nearly every aspect of neuronal development and function. This diversity of functions is often attributed to actin regulatory proteins, although how the composition of the actin cytoskeleton itself may influence its function is often overlooked. In neurons, the actin cytoskeleton is composed of two distinct isoforms, β- and γ-actin. Functions for β-actin have been investigated in axon guidance, synaptogenesis, and disease. Insight from loss-of-function in vivo studies has also revealed novel roles for β-actin in select brain structures and behaviors. Conversely, very little is known regarding functions of γ-actin in neurons. The dysregulation or mutation of both β- and γ-actin has been implicated in multiple human neurological disorders, however, demonstrating the critical importance of these still poorly understood proteins. This chapter highlights what is currently known regarding potential distinct functions for β- and γ-actin in neurons as well as the significant areas that remain unexplored.
| Original language | English (US) |
|---|---|
| Title of host publication | International Review of Cell and Molecular Biology |
| Publisher | Elsevier Inc. |
| Pages | 157-213 |
| Number of pages | 57 |
| DOIs | |
| State | Published - Jan 1 2013 |
Publication series
| Name | International Review of Cell and Molecular Biology |
|---|---|
| Volume | 301 |
| ISSN (Print) | 1937-6448 |
Fingerprint
Keywords
- Actin
- Axon guidance
- Behavior
- Dendritic spines
- Growth cones
- Hippocampus
- MRNA localization
- Neurons
Cite this
Actin Isoforms in Neuronal Development and Function. / Cheever, Thomas R.; Ervasti, James M.
International Review of Cell and Molecular Biology. Elsevier Inc., 2013. p. 157-213 (International Review of Cell and Molecular Biology; Vol. 301).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Actin Isoforms in Neuronal Development and Function
AU - Cheever, Thomas R.
AU - Ervasti, James M
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The actin cytoskeleton contributes directly or indirectly to nearly every aspect of neuronal development and function. This diversity of functions is often attributed to actin regulatory proteins, although how the composition of the actin cytoskeleton itself may influence its function is often overlooked. In neurons, the actin cytoskeleton is composed of two distinct isoforms, β- and γ-actin. Functions for β-actin have been investigated in axon guidance, synaptogenesis, and disease. Insight from loss-of-function in vivo studies has also revealed novel roles for β-actin in select brain structures and behaviors. Conversely, very little is known regarding functions of γ-actin in neurons. The dysregulation or mutation of both β- and γ-actin has been implicated in multiple human neurological disorders, however, demonstrating the critical importance of these still poorly understood proteins. This chapter highlights what is currently known regarding potential distinct functions for β- and γ-actin in neurons as well as the significant areas that remain unexplored.
AB - The actin cytoskeleton contributes directly or indirectly to nearly every aspect of neuronal development and function. This diversity of functions is often attributed to actin regulatory proteins, although how the composition of the actin cytoskeleton itself may influence its function is often overlooked. In neurons, the actin cytoskeleton is composed of two distinct isoforms, β- and γ-actin. Functions for β-actin have been investigated in axon guidance, synaptogenesis, and disease. Insight from loss-of-function in vivo studies has also revealed novel roles for β-actin in select brain structures and behaviors. Conversely, very little is known regarding functions of γ-actin in neurons. The dysregulation or mutation of both β- and γ-actin has been implicated in multiple human neurological disorders, however, demonstrating the critical importance of these still poorly understood proteins. This chapter highlights what is currently known regarding potential distinct functions for β- and γ-actin in neurons as well as the significant areas that remain unexplored.
KW - Actin
KW - Axon guidance
KW - Behavior
KW - Dendritic spines
KW - Growth cones
KW - Hippocampus
KW - MRNA localization
KW - Neurons
UR - http://www.scopus.com/inward/record.url?scp=84872405079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872405079&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-407704-1.00004-X
DO - 10.1016/B978-0-12-407704-1.00004-X
M3 - Chapter
C2 - 23317819
AN - SCOPUS:84872405079
T3 - International Review of Cell and Molecular Biology
SP - 157
EP - 213
BT - International Review of Cell and Molecular Biology
PB - Elsevier Inc.
ER -