Actin Isoforms in Neuronal Development and Function

Thomas R. Cheever, James M Ervasti

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

The actin cytoskeleton contributes directly or indirectly to nearly every aspect of neuronal development and function. This diversity of functions is often attributed to actin regulatory proteins, although how the composition of the actin cytoskeleton itself may influence its function is often overlooked. In neurons, the actin cytoskeleton is composed of two distinct isoforms, β- and γ-actin. Functions for β-actin have been investigated in axon guidance, synaptogenesis, and disease. Insight from loss-of-function in vivo studies has also revealed novel roles for β-actin in select brain structures and behaviors. Conversely, very little is known regarding functions of γ-actin in neurons. The dysregulation or mutation of both β- and γ-actin has been implicated in multiple human neurological disorders, however, demonstrating the critical importance of these still poorly understood proteins. This chapter highlights what is currently known regarding potential distinct functions for β- and γ-actin in neurons as well as the significant areas that remain unexplored.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
PublisherElsevier Inc.
Pages157-213
Number of pages57
DOIs
StatePublished - Jan 1 2013

Publication series

NameInternational Review of Cell and Molecular Biology
Volume301
ISSN (Print)1937-6448

Fingerprint

Actins
Protein Isoforms
Actin Cytoskeleton
Neurons
Nervous System Diseases
Proteins
Mutation
Brain
Chemical analysis

Keywords

  • Actin
  • Axon guidance
  • Behavior
  • Dendritic spines
  • Growth cones
  • Hippocampus
  • MRNA localization
  • Neurons

Cite this

Cheever, T. R., & Ervasti, J. M. (2013). Actin Isoforms in Neuronal Development and Function. In International Review of Cell and Molecular Biology (pp. 157-213). (International Review of Cell and Molecular Biology; Vol. 301). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407704-1.00004-X

Actin Isoforms in Neuronal Development and Function. / Cheever, Thomas R.; Ervasti, James M.

International Review of Cell and Molecular Biology. Elsevier Inc., 2013. p. 157-213 (International Review of Cell and Molecular Biology; Vol. 301).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cheever, TR & Ervasti, JM 2013, Actin Isoforms in Neuronal Development and Function. in International Review of Cell and Molecular Biology. International Review of Cell and Molecular Biology, vol. 301, Elsevier Inc., pp. 157-213. https://doi.org/10.1016/B978-0-12-407704-1.00004-X
Cheever TR, Ervasti JM. Actin Isoforms in Neuronal Development and Function. In International Review of Cell and Molecular Biology. Elsevier Inc. 2013. p. 157-213. (International Review of Cell and Molecular Biology). https://doi.org/10.1016/B978-0-12-407704-1.00004-X
Cheever, Thomas R. ; Ervasti, James M. / Actin Isoforms in Neuronal Development and Function. International Review of Cell and Molecular Biology. Elsevier Inc., 2013. pp. 157-213 (International Review of Cell and Molecular Biology).
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