Actin Isoforms in Neuronal Development and Function

Thomas R. Cheever, James M. Ervasti

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

The actin cytoskeleton contributes directly or indirectly to nearly every aspect of neuronal development and function. This diversity of functions is often attributed to actin regulatory proteins, although how the composition of the actin cytoskeleton itself may influence its function is often overlooked. In neurons, the actin cytoskeleton is composed of two distinct isoforms, β- and γ-actin. Functions for β-actin have been investigated in axon guidance, synaptogenesis, and disease. Insight from loss-of-function in vivo studies has also revealed novel roles for β-actin in select brain structures and behaviors. Conversely, very little is known regarding functions of γ-actin in neurons. The dysregulation or mutation of both β- and γ-actin has been implicated in multiple human neurological disorders, however, demonstrating the critical importance of these still poorly understood proteins. This chapter highlights what is currently known regarding potential distinct functions for β- and γ-actin in neurons as well as the significant areas that remain unexplored.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
PublisherElsevier Inc.
Pages157-213
Number of pages57
DOIs
StatePublished - 2013

Publication series

NameInternational Review of Cell and Molecular Biology
Volume301
ISSN (Print)1937-6448

    Fingerprint

Keywords

  • Actin
  • Axon guidance
  • Behavior
  • Dendritic spines
  • Growth cones
  • Hippocampus
  • MRNA localization
  • Neurons

Cite this

Cheever, T. R., & Ervasti, J. M. (2013). Actin Isoforms in Neuronal Development and Function. In International Review of Cell and Molecular Biology (pp. 157-213). (International Review of Cell and Molecular Biology; Vol. 301). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407704-1.00004-X