Actin cytoskeleton: Thinking globally, actin' locally

Lorene M. Lanier; Frank B. Gertler

doi:10.1016/S0960-9822(00)00685-0

Actin cytoskeleton: Thinking globally, actin' locally

Lorene M. Lanier, Frank B. Gertler

Neuroscience

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP₂ in the plasma membrane. Local release of PIP₂ controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.

Original language	English (US)
Pages (from-to)	R655-R657
Journal	Current Biology
Volume	10
Issue number	18
DOIs	https://doi.org/10.1016/S0960-9822(00)00685-0
State	Published - Sep 21 2000

Bibliographical note

Funding Information:
L.M.L. is supported by NIH fellowship 7F32NS10655. Work in F.B.G.'s laboratory is supported by NIH grant GM58801.

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10.1016/S0960-9822(00)00685-0

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title = "Actin cytoskeleton: Thinking globally, actin' locally",

abstract = "A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.",

author = "Lanier, {Lorene M.} and Gertler, {Frank B.}",

note = "Funding Information: L.M.L. is supported by NIH fellowship 7F32NS10655. Work in F.B.G.'s laboratory is supported by NIH grant GM58801.",

year = "2000",

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AU - Lanier, Lorene M.

AU - Gertler, Frank B.

N1 - Funding Information: L.M.L. is supported by NIH fellowship 7F32NS10655. Work in F.B.G.'s laboratory is supported by NIH grant GM58801.

PY - 2000/9/21

Y1 - 2000/9/21

N2 - A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.

AB - A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.

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DO - 10.1016/S0960-9822(00)00685-0

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JO - Current Biology

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Actin cytoskeleton: Thinking globally, actin' locally

Abstract

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