Actin cytoskeleton: Thinking globally, actin' locally

Lorene M. Lanier, Frank B. Gertler

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.

Original languageEnglish (US)
Pages (from-to)R655-R657
JournalCurrent Biology
Issue number18
StatePublished - Sep 21 2000

Bibliographical note

Funding Information:
L.M.L. is supported by NIH fellowship 7F32NS10655. Work in F.B.G.'s laboratory is supported by NIH grant GM58801.


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