Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

Gözde Genç; Ayşegül Batigün; Oǧuz Bayraktar; Özcan Altintaş; Ümit Tunca; Gürkan Hizal

doi:10.1109/BIYOMUT.2009.5130339

Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

Translated title of the contribution: Acrylic star block copolymers as hydrophobic drug carriers

Gözde Genç, Ayşegül Batigün, Oǧuz Bayraktar, Özcan Altintaş, Ümit Tunca, Gürkan Hizal

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.

Translated title of the contribution	Acrylic star block copolymers as hydrophobic drug carriers
Original language	Turkish
Title of host publication	Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
DOIs	https://doi.org/10.1109/BIYOMUT.2009.5130339
State	Published - 2009
Externally published	Yes
Event	2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 - Balcova, Izmir, Turkey Duration: May 20 2009 → May 22 2009

Publication series

Name	Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

Conference

Conference	2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
Country/Territory	Turkey
City	Balcova, Izmir
Period	5/20/09 → 5/22/09

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10.1109/BIYOMUT.2009.5130339

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Genç, G., Batigün, A., Bayraktar, O., Altintaş, Ö., Tunca, Ü., & Hizal, G. (2009). Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler. In Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 [5130339] (Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009). https://doi.org/10.1109/BIYOMUT.2009.5130339

Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler. / Genç, Gözde; Batigün, Ayşegül; Bayraktar, Oǧuz et al.
Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009. 2009. 5130339 (Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Genç, G, Batigün, A, Bayraktar, O, Altintaş, Ö, Tunca, Ü & Hizal, G 2009, Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler. in Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009., 5130339, Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009, 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009, Balcova, Izmir, Turkey, 5/20/09. https://doi.org/10.1109/BIYOMUT.2009.5130339

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title = "Hidrofobik {\.i}la{\c c} ta{\c s}iyicisi olarak akrilik yildiz blok kopolimerler",

abstract = "Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.",

author = "G{\"o}zde Gen{\c c} and Ay{\c s}eg{\"u}l Batig{\"u}n and Oǧuz Bayraktar and {\"O}zcan Altinta{\c s} and {\"U}mit Tunca and G{\"u}rkan Hizal",

year = "2009",

doi = "10.1109/BIYOMUT.2009.5130339",

language = "Turkish",

isbn = "9781424436064",

series = "Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009",

booktitle = "Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009",

note = "2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 ; Conference date: 20-05-2009 Through 22-05-2009",

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T1 - Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

AU - Genç, Gözde

AU - Batigün, Ayşegül

AU - Bayraktar, Oǧuz

AU - Altintaş, Özcan

AU - Tunca, Ümit

AU - Hizal, Gürkan

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N2 - Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.

AB - Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.

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BT - Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

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Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

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