Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

Translated title of the contribution: Acrylic star block copolymers as hydrophobic drug carriers

Gözde Genç, Ayşegül Batigün, Oǧuz Bayraktar, Ozcan Altintas, Ümit Tunca, Gürkan Hizal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.

Translated title of the contributionAcrylic star block copolymers as hydrophobic drug carriers
Original languageTurkish
Title of host publicationProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
DOIs
StatePublished - Oct 27 2009
Event2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 - Balcova, Izmir, Turkey
Duration: May 20 2009May 22 2009

Publication series

NameProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

Conference

Conference
CountryTurkey
CityBalcova, Izmir
Period5/20/095/22/09

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