Acrodermatitis enteropathica and an overview of zinc metabolism

Emanual Maverakis, Maxwell A. Fung, Peter J. Lynch, Michelle Draznin, Daniel J. Michael, Beth Ruben, Nasim Fazel

Research output: Contribution to journalReview articlepeer-review

294 Scopus citations


Acrodermatitis enteropathica is a rare autosomal recessive disorder of zinc deficiency. The genetic defect has been mapped to 8q24 and the defective gene identified as SLC39A4, which encodes the zinc transporter Zip4. The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency.

Original languageEnglish (US)
Pages (from-to)116-124
Number of pages9
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - Jan 2007
Externally publishedYes


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