Acquired resistance to immune checkpoint blockade therapies

Xianda Zhao, Dechen Wangmo, Matthew Robertson, Subbaya Subramanian

Research output: Contribution to journalReview article

Abstract

Immune checkpoint blockade therapy (ICBT) has revolutionized the treatment and management of numerous cancers, yet a substantial proportion of patients who initially respond to ICBT subsequently develop resistance. Comprehensive genomic analysis of samples from recent clinical trials and pre-clinical investigation in mouse models of cancer provide insight into how tumors evade ICBT after an initial response to treatment. Here, we summarize our current knowledge on the development of acquired ICBT resistance, by examining the mechanisms related to tumor-intrinsic properties, T-cell function, and tumor-immune cell interactions. We discuss current and future management of ICBT resistance, and consider crucial questions remaining in this field of acquired resistance to immune checkpoint blockade therapies.

Original languageEnglish (US)
Article number1161
JournalCancers
Volume12
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • Acquired resistance
  • CTLA-4
  • Immune checkpoint blockade
  • Immune response
  • PD-1
  • T cells
  • Tumor immunology

PubMed: MeSH publication types

  • Journal Article
  • Review

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