Acquired factor XI deficiency in systemic lupus erythematosus

G. M. Vercellotti, D. F. Mosher

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A variety of coagulation abnormalities has been described in systemic lupus erythematosus (SLE). We report a unique SLE patient with an acquired factor XI deficiency. The low factor XI levels were not due to a classical coagulation inhibitor, but to a plasma factor (probably an immunoglobulin) that selectively bound factor XI. The factor XI deficiency improved after treatment with corticosteroids. Thus it is possible that in SLE immune complexes may bind clotting factors making them unavailable for use in the coagulation cascade.

Original languageEnglish (US)
Pages (from-to)250-252
Number of pages3
JournalThrombosis and Haemostasis
Volume48
Issue number3
DOIs
StatePublished - 1982

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